Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
RESEARCH LETTERS
Wistar-Imamichi Rats Exhibit a Strong Resistance to Cadmium Toxicity
Hideaki ShimadaMasaaki NaganoAkira YasutakeYorishige Imamura
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2002 年 48 巻 2 号 p. 201-203

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The strain difference in the toxicity of cadmium (Cd) was examined in male rats. All rats of the Wistar-Imamichi (Wistar-IM) strain survived for 7 days after treatment with Cd at a dose of 5.0 mg/kg body weight, whereas 80% of the Wistar strain and 100% of the Sprague-Dawley and Fischer strains died. These results indicate that the Wistar-IM strain has strong resistance to Cd. Furthermore, the metallothionein (MT) contents of the liver, kidney and testis of Wistar-IM rats were compared with those of Fischer rats. The strain difference in the toxicity of Cd in rats did not appear to result from a difference in MT content, although further study is necessary to elucidate the role of MT.

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© 2002 by The Pharmaceutical Society of Japan
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