Journal of Health Science
Online ISSN : 1347-5207
Print ISSN : 1344-9702
ISSN-L : 1344-9702
RESEARCH LETTERS
Effect of Carbon Tetrachloride on 3′-AMP-Forming Enzyme Activity in Rat Liver
Hiroyuki FujimoriHidemitsu Pan-Hou
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2002 年 48 巻 2 号 p. 204-207

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The effect of carbon tetrachloride (CCl4) on adenosine 3′-monophosphate (3′-AMP) content and 3′-AMP-forming enzyme activity in rat liver was examined. The levels of 3′-AMP and the total amounts of adenosine 5′-triphosphate, adenosine 5′-diphosphate and adenosine 5′-monophosphate were decreased by treatment with CCl4. The 3′-AMP-forming enzyme activity in CCl4-treated rat liver homogenate was ca. 4-fold higher than that of control. The enzyme activity in CCl4-treated mitochondria was ca. 50% of control values. These results suggest that the increase in the 3′-AMP-forming enzyme activity in the cytosol may be, at least partly, due to the leakage of the enzyme activity from mitochondria in acute hepatitis induced by CCl4.

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© 2002 by The Pharmaceutical Society of Japan
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