Characteristic Properties of Genipin as an Activator in Neuronal Nitric Oxide Synthase

Hirokazu Suzuki; Matsumi Yamazaki; Kenzo Chiba; Hiroyuki Sawanishi

doi:10.1248/jhs.53.730

REGULAR ARTICLES

Characteristic Properties of Genipin as an Activator in Neuronal Nitric Oxide Synthase

Hirokazu Suzuki, Matsumi Yamazaki, Kenzo Chiba, Hiroyuki Sawanishi

著者情報

キーワード: genipin, tetrahydrobiopterin, 4-aminotetrahydrobiopterin, molecular modeling, neuronal nitric oxide synthase

ジャーナルフリー

2007 年 53 巻 6 号 p. 730-733

DOI https://doi.org/10.1248/jhs.53.730

詳細

抄録

The present investigation was undertaken to compare the structural and electronic properties of genipin with those of tetrahydrobiopterin (H₄B), an essential cofactor in neuronal nitric oxide synthase (nNOS), and 4-aminotetrahydrobiopterin (4-amino-H₄B), an inhibitor of nNOS, using computer-assisted molecular modeling techniques. Molecular modeling, superimposing, and docking simulation, in addition to LUMO-energy calculation, revealed that genipin has structural and electronic properties that markedly resemble those of H₄B.

責任著者(Corresponding author)

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