抄録
The effects of oral administration of polysaccharide sulphate have hitherto seemed to be questionable. Now, it was understood that the effect of dextran sulphate depends on the content of sulfur, so the influences of digestive juice to dextran sulphate of various contents of sulfur and of limited viscosities were examined in order to investigate the effect of oral administration of dextran sulphate. Dextran sulphate was considerably decomposed in artificial gastric juice, showing the inereasing decomposition rate with the decrease of sulfur content, and was also decomposed in hydrochloric acid solution and its rate was slightly less than in gastric juice but exhibited the similan tendency. The inactivation of pepsin by dextran sulphate increased with the sulfur content. Dextran sulphate was also decomposed in artificial intestinal juice and its rate was increased with decrease of sulfur content but was extremely less than in artificial gastric juice.
