解熱鎮痛剤中のアセチルサリチル酸, バルビタール(ピラビタール中のものを含む)の分離定量

抄録

Acetylsalicylic acid and barbital in pharmaceutical preparations were determined by the A.O.A.C. and isopropylamine-cobalt acetate method respectively. The influences of the coexisted substances on the above mentioned chemicals were also examined. Quantitative thin-layer chromatographic analysis of acetylsalicylic acid and barbital was achieved by carrying out on a micro scale with a high degree of precision, simplicity and rapidity. The spots were scraped from the plates and the fractions of acetylsalicylic acid and barbital which were extracted with chloroformmethanol, acetic acid-chloroform and acetone-methanol from the silica gel, were determined by colorimetric and UV absorption method. The routine separation analysis of acetylsalicylic acid and barbital may be performed by this method.