解熱鎮痛剤中のアミノピリンの非水滴定による定量法

抄録

For the determination of aminopyrine, the colorimetric method, oxidative-titration and chelatetitration have been reported, but they were not often applied to the case of mixed pharmaceutical preparations, because of specificity and sensitivity. Present paper reports the determination method of aminopyrine in the mixed preparation by the use of non-aqueous titration. Aminopyrine was isolated from mixed preparation by ether or chloroform extraction and potentiometrically titrated with perchlorate in acetic acid solution. In the case of internal medicine with coexistence of sulpyrine, quantitative determination of aminopyrine, which has hitherto been difficult, could be attained by using solvent of acetic anhydride and acetic acid. Satisfactory results were obtained with the model sample and commercial preparation. Chlorophenylamine maleate, noscapine-HCl, sulpyrine, caffeine, phenacetine and ephedrine did not affect the titration value in ordinary doses.