ガスクロマトグラフィーによる局所麻酔剤の分析

抄録

Gas-liquid chromatography of 10 kinds of local anesthetics has been carried out on 1 m column packed with Daichrom A (washed Celite 545) coated with 1% silicone QF-1 or with Daichrom F (quartz powder) coated with 0.5% thermol No. 3. Each sample (in free base state) in ethanolic solution was introduced into gas chromatograph equipped with hydrogen flame ionization detector. The column with thermol No. 3 was preferred for the separation of all these drugs including dibucaine which had been difficult to detect with gas-liquid chromatography. Rapid and superior separation of a mixture of these drugs was also performed by thermol No. 3 column using a temperature gradient.