重金属の体内挙動に関する研究ラット小腸粘膜上清成分とカドミウムの結合

抄録

In order to examine the physiological behavior of orally ingested cadmium, its interaction with the small intestinal mucosa was examined. The 105000×g mucosal soluble fraction from the small intestine of a rat given^115m CdCl₂ orally was fractionated by gel filtration. Majority of cadmium in the mucosal soluble fraction was present in the state bound to high-molecular compound (s) and the main bound component of these eluted from the gel filtration column in the same position as the cadmium-bound protein (metallothionein) in the liver and kidney. The amount of cadmium bound to components in the mucosal soluble fraction remained almost constant for 24 hr after administration but the majority disappeared from the mucosal soluble fraction after 48hr. It was also found that majority of cadmium in the intestinal content and feces of rats given cadmium orally was in the state bound to high-molecular compound (s).