抄録
Seven kinds of metabolites of o-sec-butylphenyl N-methylcarbamate (BPMC) were examined for their anticholinesterase activity to see whether metabolites more potent than BPMC itself were present or not. The products with N-methylhydroxylated or demethylated and alkyl side-chains hydroxylated or carboxylated showed no activity corresponding to BPMC, and it was recognized that metabolism was progressed towards detoxication. Relative intensity of anticholinesterase activity of each of these metabolites for pseudo- and true cholinesterase was similar.
