抄録
Lifestyle diseases such as cancer, heart disease, cerebrovascular disease, are the three
leading causes of death among the Japanese, and the prevention of lifestyle diseases is
an important issue in Japan. Daily high energy intake and high fat diet are involved in
the onset of lifestyle diseases, and nutritional therapy is important for the prevention
of lifestyle diseases. Nutritional therapy for lifestyle diseases is based on scientific
data which is important to be established. The authors found that lipid nutrition for
insulin resistance and non-alcoholic fatty liver disease （NAFLD） from the association of
physical measurement, clinical data, nutrient intake and plasma fatty acid composition.
As a result, it was suggested that the low levels of n-3 Polyunsaturated Fatty Acids （n-3
PUFA） in plasma phospholipid may be related to insulin resistance, and the decrease
in n-3 PUFA intake was also involved in the rise in n-6/n-3 ratio. It was also suggested
that increasing NAFLD Score not only reduces energy intake, but also increases fish
and n-3 PUFA intakes. The clarification that n-3 PUFA intakes of eicosapentaenoic acid
and docosahexaenoic acid is involved in the prevention and improvement of lifestyle
related diseases in elucidating the nutritional therapy of lipids in lifestyle related
diseases has revealed the importance of lipid nutrition in lifestyle related diseases. It is
thought that it contributes to the establishment of nutritional therapy of lipid.
