殺菌燈照射油脂のマウスに対する毒性について
1971 年 20 巻 5 号 p. 298-303
詳細
1971 年 20 巻 5 号 p. 298-303
To investigate acute and sub-acute toxicity of edible oil irradiated by a germicidal lamp was performed with mice as test animals.
The acute toxicity was determined by a single peroral administration of the irradiated oil into mice. The mice in the test group showed a reduction of the body weight and some animals died in case of intaking the highly irradiated oil. No histopathological changes were observed except dilatation of the gut.
For observation of short and long-term toxicity the mice were fed with diets containing 10% of the irradiation oil ad libitum for 4 weeks and for 17 weeks. General symptoms, body weight, organ weight, blood count, liver function tests, liver and plasma lipid composition and pathological examinations were carried out to investigate the biomedical effects of the oil on the test animals.
An atrophy and anemia in the spleen were observed in the early stage of the feeding period, within 12 weeks. Especially, blood count varied markedly, that is, a number of red blood cells decreased and that of white blood cells increased.
In the late stage of the feeding period, fatty acid composition in the liver of the animals fed with the irradiated oil was obviously changed as compared with that of the control oil group. The enlargement of the liver was also observed in the group of irradiated oil.
At the 17th week of feeding by the irradiated oil, the liver of the animals tested showed a slight damage by functional tests and morphological observation.
