抄録
Lithium naphthalenide reacts with carboxylic acids containing two hydrogen at 2-position in the presence of diethylamine to give the dianions of carboxylic acids. Reaction of these dianions with epoxides gives the corresponding dianions of 4-hydroxy acids. These dianions of 4-hydroxy acids give corresponding trianions of 4-hydroxy acids by the action of lithium naphthalenide. Treetment of these trianions react with epoxides followed by hydrolysis give 4, 4'-dihydroxy acids. The 4, 4'-dihydroxy acids easily cyclize to give γ-butyrolactones containing hydroxy groups in their side chains. Oxidation of these lactones gives γ-butyrolactones containing carbonyl groups in their side chains.
