人工生体膜モデル・リポソーム (ベシクル) の示差走査熱量測定による熱化学状態解析

抄録

Representative, three types of phospholipid vesicles such as SUV (small unilamellar vesicle), LUV (large unilamellar vesicle) and MLV (multilamellar vesicle) were thermodynamically investigated by high sensitivity differential scanning calorimetry (DSC). A phase transition of gelto-liquid crystal of these vesicles was characterized by the transition temperature, transition enthalpy, transition entropy, van't Hoff enthalpy and the cooperative unit. Based on these thermal quantities, the present study discussed the thermodynamic stability of the vesicle system and also the aggregation state as well as the motional state of the lipid molecules in their assembly of vesicle.