光音響分光法によるin vitro経皮吸収評価法の研究
1992 年 41 巻 7 号 p. 558-562
詳細
1992 年 41 巻 7 号 p. 558-562
In this study, a novel application photoacoustic spectroscopy (PAS) was examined in vitro percutaneous absorption. Various aliphatic compounds were used as model samples. In vitro percutaneous absorptiometry was conducted by applying model samples to the skin of a hairless pig. Decrease in the amount of drug applied to a membrane could be measured by the PAS method.
The percutaneous absorption rate when using ESCALLOL-557 was found to be 0.101 mg/h in the drug side and that in the pig skin side, 0.117 mg/h. The amount of drug which penetrated the pig skin as determined by the PAS method agreed with the isotope measurement.
The diffusion mechanism in this experimental system was penetration diffusion ; the diffusion coefficient was 10-5 cm2/h, which was consistent with that found by Flynn. The present results demonstrated the usefulness of this novel percutaneous absorptiometry in conjunction with the PAS method.
