生体における過酸化脂質の生成とその生理作用

リン脂質過酸化反応を中心に

抄録

Lipid peroxidation in biological system proceeds via enzymatic and nonenzymatic reaction resulting in the formation of biologically active substances. Peroxidation of biomembrane phospholipids happens by the attack of active oxygens and thereby function of biomembranes are damaged. However, this reaction seems to be of physiologically importance. For example, enzymatic peroxidation of membrane phospholipids occurs in the maturation of red cells. Platelet activating factor (PAF) -like phospholipid peroxidation products can be formed by nonenzymatic process. Pathological and physiological aspects should be evaluated in the peroxidation of membrane phospholipids.