6- [(8Z, 11Z) -8, 11, 14-ペンタデカトリエニル] サリチル酸誘導体のチロシナーゼ活性阻害について

抄録

For the effective utilization of compounds obtained from nature, we synthesized derivatives considered to possibly have physiological activity, using 6- [(8 Z, 11 Z) -8, 11, 14-pentadecatrienyl] salicylic acid (1) from cashew nut shell oil as the starting material. Eight derivatives were obtained via acetylation, methylation and/or oxidation of (1). They were examined for capacity to inhibit tyrosinase and found to inhibit its activity more than (1).