The Posterior Nasal Nerve Plays an Important Role on Cardiopulmonary Reflexes to Nasal Application of Capsaicin, Distilled Water and l-Menthol in Anesthetized Dogs

Arata KANAMARU; Tatsushi MUTOH; Kentaro KOJIMA; Ryohei NISHIMURA; Nobuo SASAKI; Masayoshi KUWAHARA; Hirokazu TSUBONE

doi:10.1292/jvms.61.85

Arata KANAMARU, Tatsushi MUTOH, Kentaro KOJIMA, Ryohei NISHIMURA, Nobuo SASAKI, Masayoshi KUWAHARA, Hirokazu TSUBONE

Author information

Arata KANAMARU
Departments of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Tatsushi MUTOH
Department of Pediatic and Internal Medicine, School of Medicine, University of California, Davis, CA95616, U.S.A.
Kentaro KOJIMA
Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Ryohei NISHIMURA
Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Nobuo SASAKI
Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Masayoshi KUWAHARA
Departments of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Hirokazu TSUBONE
Departments of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

Keywords: canine, control of breathing, trigeminal nerve afferent

JOURNAL FREE ACCESS

1999 Volume 61 Issue 1 Pages 85-88

DOI https://doi.org/10.1292/jvms.61.85

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Abstract

The sensory innervation of the cardiopulmonary reflexes to nasal application of capsaicin (CAPS), distilled water (DW) and l-menthol (LM) was studied in anesthetized dogs breathing through tracheostomy. A marked cardiopulmonary reflex was observed by CAPS and DW into the nasal cavity, while a prolongation of expiration was induced by LM. All these reflexes were significantly decreased by bilateral section of the posterior nasal nerve (PNN) and completely abolished by topical nasal anesthesia with lidocaine. Responses of the whole nerve activity of the PNN to these substances corresponded to the magnitude of the reflexes. These results indicate that PNN afferents play an important role on the reflex elicitation of the noxious, water and cold stimuli from the nasal cavity.

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