抄録
Effects of pH and temperature of the bath water on the uptake of oxolinic acid by goldfish Carassius auratus were examined.
The one-compartment model having two pharmacokinetic parameters, the volume of dis-tribution and clearance constant, was used to analyze the data. The model fitted the accumulation data except for a few places. The equilibrium concentration in goldfish at pH 6.0, 6.9 and 7.7 were 74.7, 23.4 and 11.5μg/g, respectively. Thus, the degree of accumulation was greater at pH below the pKa (=6.9) of oxolinic acid. The clearance constant was in the range of 0.39-0.56ml/h/g, and the volume of distribution was in the range of 1.65-2.19 ml/g at various water tem-neratures under the constant pH of 6.9, and both values increased with water temperature.
