The seasonal variation of lysozyme activity and six principal constituents of the short-necked clam, Tapes philippinarum, collected off the coast of Funabashi City was investigated over a period of 12 months. Lysozyme activity was assayed in the use of Micrococcus lysodeikticus cells as substrate. A high lysozyme activity in the short-necked clams collected in December and a low activity in those collected in April were observed. The lysozyme activity and water content of the whole body were positively correlated. On the other hand, the lysozyme activity and glycogen con-tent, which is closely related to the ponderal index, were negatively correlated. It appears that the lysozyme activity of the short-necked clam increases when the body constituents are physiologically exhausted.