抄録
Flavin in the living tissue of atypical epithelioma was estimated to be 1.2γ/g composed of FAD (1.0 μg/g), FMN (0.16 μg/g), and riboflavin (0.04 μg/g), and that of its necrotic tissue was 0.8 μg/g composed of FAD (0.23 μg/g), FMN (0.53 μg/g) and riboflavin (0.04 μg/g). Total amounts of flavins in the organs of tumour bearing rat were decreased with the growth of tumour, reaching to be 18.0 μg/g in the liver, 22.6 μg/g in the kidney, and 10.3 μg/g in the heart at the end of the 4th week. The decrease of the total amount of flavin was attributed to the decrease of FAD. The administration of FAD elevated the amount of flavins in these organs, but the amount reached nearly the level of control after 5 hours. The administration of riboflavin-5'-monosulfate did not provoke any marked change in distribution of flavins in the organs of these rats.
