抄録
Safety evaluation of thiamine monophosphate disulfide (TMPDS) was made by chronic toxicity and teratological tests. In the chronic toxicity test, TMPDS was administered to rats intraperitoneally in doses of 100 and 50 mg/kg daily for six months. Between the control and the animals injected with TMPDS was observed no difference in the body weight gain, food consumption, hematologic findings, organ weights and histologic findings. In the teratological test, 500,100 and 50 mg/kg of TMPDS were given intraperitoneally to pregnant rats and mice every day from the 7th to the 14th day of gestation. No influence of TMPDS was observed on both fetuses and newborns obtained from the mother animals.
