O-Nicotinylthiamine disulfideにかんする研究 : (III)生物学的性質
1969 年 39 巻 6 号 p. 386-390
詳細
1969 年 39 巻 6 号 p. 386-390
Some biological properties of O-nicotinylthiamine disulfide (NTDS) was investigated. (1) Its thiamine activity was approximately equivalent to that of thiamine hydrochlorides in thiamine-deficient rats. (2) Oral administration of NTDS resulted in for higher thiamine level in the blood as well as on the liver and kindney. (3) After oral administration of NTDS to mouse resulted in long retention of thiamine concentration in the whole body. (4) One hour after administation of NTDS for intestinal wall brought about higher thiamine level than thiamine. (5) NTDS was definitely resistant to thiaminase I or II produced by Bacillus thiaminolyticus or B. aneurinolyticus, respectively.
