抄録
Pyridoxal (PL) or saline as a control was administered intraperitonealy to mice fed vitamin B_6 deficient diets or B_6 standard diets with normal protein level for 24 days. The mice were fasted for 16 hours and then supplied each diet for limited 30 minutes. At one and half hours after pyridoxal administration to the retake mice, the mice were sacrificed to collect their blood and livers. Body weights and serum alanine aminotransferase values of B_6 deficient groups were significantly decreased compared with that of control group. In the case of pyridoxal administration to B_6 deficient groups, the blood glucose levels as well as the insulin concentrations in serum were significantly decreased. In contrast, the amounts of coenzyme forms of B_6 (pydoxal 5'-phosphate+pyridoxamine 5'-phosphate) and glucose-6-phosphatase activities in the livers increased significantly compared with that of saline administrated group to B_6 deficient group. These results suggest that the insulin levels in serum of B_6 deficient mice decreased and the glucose-6-phosphatase activities increased by PL administration.
