YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
イソヒノリン誘導体の合成研究 (第12報)
イミダァツォイソヒノリン誘導体の合成研究 (その9) 9, 10-Dimethoxy-3-(cinchonyl)-5, 6-dihydrobenzoglyoxalocolineの合成
亀谷 哲治飯田 英夫
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1951 年 71 巻 9 号 p. 1004-1006

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抄録
With the same objective in view, imidazoisoquinoline possessing a quinoline group in the 3-position, i.e. 9, 10-dimethoxy-3-cinchonyl-5, 6-dihydrobenzoglyoxalocoline, was synthesized. In this instance, differing from previous experiments, the azide, obtained during the preparation of cinchonyl-β-veratrylethylamide, is quite unstable and must be treated at once and also, if left in alkaline state, it rapidly becomes red colored. Addition of phosphorus oxychloride for its cyclization also results in its coloration to dark purple. The free base softens at 60° and decomposes at 85°, but its picrate and hydrochloride show definite melting points.
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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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