医薬品の吸収と排泄に関する研究 (第6報)

クロラムフェニコールのシロネズミ胃および小腸からの吸収ならびに吸収に及ぼす金属塩の影響

抄録

Absorption of chloramphenicol from the stomach and small intestine of a rat was examined with solutions of various pH and the effect of metal salts on this absorption was examined. For absorption through the stomach, a definite quantity of chloramphenicol solution was injected into the rat stomach, the liquid was taken out after 1hour, and absorption rate was calculated from the decrease in its weight. For absorption through the intestinal canal, a definite quantity of the sample solution was perfused through the rat small intestine, the sample was taken out after 0.5, 1.0, and 1.5hours, and the amount of chloramphenicol was determined. Absorption rate was calculated from the decrease in weight. It was thereby found that absorption rate through the stomach was around 10% with solutions of various pH but approximately 50% absorption rate was found after 1.5 hours. The absorption rate was also examined with sample solutions added with ferric chloride, calcium chloride, magnesium chloride, or aluminium chloride, and it was found that absorption of chloramphenicol from both the stomach and small intestine was inhibited by the addition of metal salt to the acid solution.