抄録
Di- and tri-methyl-substituted 19-nortestosterones were synthesized starting from 6-methoxy-4-methyl.(III) or 6-methoxy-4, 4-dimethyl-1-tetralone (IV) and 2-methyl (VIa) or 2-ethylcyclopentane-1, 3-dione (VIb). Among them the phenoxyacetate of d-6, 6-dimethyl-19-nortestosterone (XIIIb) showed a strong anabolic activity, whereas the antipode had no biological activity. The progestational activity of 6, 18-dimethyl-17α-ethynyl-19-nortestosterone (XXIVa) was 50 times that of ethisterone in the McPhail test (p.o.), but 6, 6-dimethylation of norethisterone did not increase the progestational activity.
