巻号一覧
94 巻, 2 号
選択された号の論文の23件中1～23を表示しています
- |<
- <
- 1
- >
- >|
-
原田 正敏, 天明 直美, 油田 正樹, 遠藤 徹1974 年 94 巻 2 号 p. 157-162
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーPharmacological studies were made on geniposide, genipin, and gardenia fruit extract on the first general screening test and on their effect on digestive organs, especially on biliary excretion, gastric juice secretion, and gastric contraction. Geniposide is the main component of fruits of gradenia (Gardenia jasminoides ELLIS) and genipin is its aglucone. Gardenia fruit is an important crude drug which is used in prescriptions of Chinese medicine, Shishishi-to ( ?? ?? ?? ?? ), Shishikankyo-to ( ?? ?? ?? ?? ?? ), Inchinko-to ( ?? 〓 ?? ?? ), etc., and may be expected to show sedative, anti-inflammatory, choleretic, antipyretic, and diuretic effects. In the first general screening test, geniposide and genipin inhibited the writhing behavior in mice induced by acetic acid, and genipin showed a weak anti-acetylcholine action and a weak antihistamine action on the isolated mouse. ileum and isolated guinea pig ileum, respectively. Genipin increased biliary excretion by either intravenous, intraduodenal, or oral administration in rats. The choleretic activity of genipin was almost equal to that of sodium dehydrocholate. Genipin inhibited the gastric secretion in the pylorusligated rat, the potency being 1/10 to 1/5 of atropine sulfate. Geniposide and genipin inhibited both the spontaneous contraction and the pilocarpine-induced contraction of the rat stomach. Such an inhibition, however, was transient and geniposide was less potent.抄録全体を表示PDF形式でダウンロード (865K) -
中垣 正幸, 二宮 宏1974 年 94 巻 2 号 p. 163-169
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーPorosity (ε) and tortuosity (q) of sedimentation beds were measured for aqueous suspension of yarious powders, (glass beads, sea sand, chloramphenicol, griseofulvin, and alumina) which had been dispersed in polivinylpyrolidone (PVP) and carboxymethylcellose natrium (CMC-Na) solutions. The primary (γ0) and secondary (γm) particle radius were also measured. The ratio of vertical and horizontal q values, qV/qH, is a parameter that represents the anisotropy of the sedimentation bed. According to the relations ε vs. qV/qH and qV/qH vs. γm/γ0, the sedimentation states of particles in bed were discussed. The sedimentation states of perticles show a different tendency depending on the primary particle radius (γ0).In the case of large γ0, the bed approaches isotropy with the growth of scafford structure. On the other hand, when γ0 is small, the bed becomes more anisotropic due to the formation of secondary particles of nonspherical shape.抄録全体を表示PDF形式でダウンロード (956K) -
榊原 仁作, 堀田 芳弘, 安江 政一1974 年 94 巻 2 号 p. 170-175
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーThe structure of ovalifolioside, a new triterpene monoarabinoside isolated from the leaves of Lyonia ovalifolia var. elliptica has been determined as 1β, 23-dihydroxy-3β-L-α-arabopyranosyloxyolean-12-ene (I) by chemical reactions and physical data of its derivatives. Chemical shifts of seven methyl groups of the glycoside, aglycone, and their derivatives have been assigned as shown in Table I.抄録全体を表示PDF形式でダウンロード (815K) -
沢田 洋介, 坂本 博, 谷山 兵三1974 年 94 巻 2 号 p. 176-180
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーRacemonycin-A and -C were respectively acetylated with N-acetoxysuccinimide. The structures of these derivatives were determined by dinitrophenyl derivative method. N-Acetyl-racemomycin-A exhibited a weak antimicrobial activity and the original toxicity was decreased. N-Acetyl-racemomycin-C also had lower antimicrobial activity than the original antibiotic. These results showed that ε- and ε'-amino groups of β-lysine residue in these antibiotics are an important site for appearance of their biological activity.抄録全体を表示PDF形式でダウンロード (634K) -
杉原 弘貞, 松本 憲親, 川松 豊1974 年 94 巻 2 号 p. 181-188
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーBy treatment with acetic anhydride and acetic acid, 1-(2-carboxyphenyl)-3, 4-dimethylpyrroles (1) gave 1, 2-dimethyl-9H-pyrrolo[1, 2-α]indol-9-ones (2) in a good yield. 3-Cyano derivatives (4) were synthesized by bromination of 2 with bromine or N-bromosuccinimide to 3-bromo derivatives (3) followed by treatment of the latter with cuprous cyanide. Hydrolysis of 4 gave 1, 2-dimethyl-9-oxo-9H-pyrrolo[1, 2-α]indole-3-carboxylic acids (5) and the rearranged products, whose structure was assumed as 8, 9-dimethyl-7-hydroxy-6, 10-dihydropyrido[1, 2-α]indole-6, 10-diones (6) on the basis of the spectroscopic properties. The ratio of the products 5/6 varied with the position of chloro group on the phenyl ring. Hydrolysis of 3 with aqueous potassium hydroxide yielded 1, 2-dimethyl-9-hydroxy-3H-pyrrolo[1, 2-α]indol-3-ones (11). The same product 11e was also obtained by oxidation of 2e with lead tetraacetate.抄録全体を表示PDF形式でダウンロード (1075K) -
藤田 路一, 糸川 秀治, 粂川 芳広1974 年 94 巻 2 号 p. 189-193
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーThe distribution of 3-O-acetyloleanolic acid, oleanolic acid, and hederagenin in Clematis and Akebia spp. was studied. These were isolated from the roots of C. uncinata var. ovatifolia, C. apiifolia, and C. apiifolia var. biternata. Oleanolic acid and hederagenin were isolated from the roots of C. terniflora and C. japonica, and the stems of A. quinata, A. trifoliata, and A. longeracemora, and also from the roots of C. patens, Madame Van Houtte, C. stans, and C. stans var. austrojaponensis. The stem of A. quinata contained stigmasterol, β-sitosterol, betulin, β-sitosterol β-D-glucoside, myo-inositol, and sucrose. Stigmasterol, β-sitosterol, and β-sitosterol β-D-glucoside were isolated from the root of A. quinata, and from the root and stem of A. trifoliata.抄録全体を表示PDF形式でダウンロード (736K) -
藤田 路一, 糸川 秀治, 粂川 芳広1974 年 94 巻 2 号 p. 194-198
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーThe stem of Akebia quinata contains saponins. Twelve spots of these saponins were found by thin-layer chromatography, and named akeboside Sta, Stb, Stc, Std, Ste, Stf, Stg1, Stg2, Sth, Stj, and Stk. Akeboside Stb, Stc, Std, Ste, Stf, Sth, Stj, and Stk were isolated by column chromatography. Akeboside Stb is hederagenin bonded with arabinose ; Stc is hederagenin bonded with arabinose and rhamnose ; Std is hederagenin bonded with arabinose and glucose ; Ste is oleanolic acid bonded with arabinose, glucose, and rhamnose ; Stf is hederagenin bonded with arabinose, glucose, and rhamnose ; Sth is hederagenin bonded with arabinose, glucose, and rhamnose ; Stj is oleanolic acid bonded with arabinose, glucose, and rhamnose ; and Stk is hederagenin bonded with arabinose, glucose, and rhamnose. Akebosides Stg1 and Stg2 could not be separated, but seemed to be a mixture of oleanolic acid and hederagenin bonded with arabinose, glucose, and rhamnose.抄録全体を表示PDF形式でダウンロード (664K) -
吉田 則雄, 富田 邦之1974 年 94 巻 2 号 p. 199-203
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーAs chemical modification of Bimetopyrol [2-methyl-4, 5-bis(p-methoxyphenyl)pyrrole], 2, 3-cycloalkylpyrrole compounds were prepared by the condensation of α-hydroxyketones and cycloalkanones in the presence of ammonium acetate. The synthesis of pyrrolizidinone, indole, and azaazulene compounds is also described.抄録全体を表示PDF形式でダウンロード (720K) -
中西 美智夫, 後藤 一洋1974 年 94 巻 2 号 p. 204-214
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーSince 2-(9-oxo-xanthen-2-yl)-propionic acid (Y-5554) was found to possess anti-inflammatory properties, some experiments were carried out on its activities on platelets which were obtained from rabbits, rats, and guinea-pigs. Y-5554 inhibited the collagen- and thrombin-induced platelet aggregation in platelet-rich plasma (PRP) of rabbits, rats, and guinea-pigs in vitro. This compound also inhibited the adenosine diphosphate (ADP)-induced second-phase aggregation in PRP of guinea-pigs. It also inhibited the thrombin-induced release reaction in the washed platelet suspension obtained from the animals. Y-5554 inhibited the collagen- and ADP·collagen-induced platelet aggregation in vitro, in guinea-pigs by oral administration. These inhibitory activities were found to be affected by the difference of aminal species. The inhibitory properties of Y-5554 were found to be similar to those of phenylbutazone ; Y-5554 was more active than acetylsalicylic acid and less active than indomethacin. These findings show that the inhibitory activities of Y-5554 on the platelet aggregation may be due to its protective properties on platelets. This suggests that Y-5554 may be useful for the treatment of patients with elevated platelet aggregation.抄録全体を表示PDF形式でダウンロード (1367K) -
藤田 直1974 年 94 巻 2 号 p. 215-220
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリー1) An in vivo study was made on the effect of ascorbic acid and ferrous ion on the formation of lipid peroxide on the rat liver microsomes and soluble fraction. Lipid peroxide content in microsomes and soluble fraction increased gradually with time after intraperitoneal administration of ascorbic acid (176 mg/kg/day) and ferrous chloride (28.2 mg Fe2+/kg/day). 2) Among the composition of phosphatidylserine and phosphatidylinositol, diminution of arachidonic acid and docosahexaenoic acid was predominant during increase in the formation of lipid peroxide in microsomes and soluble fraction. 3) Total sulfhydryl content of microsomes and soluble fraction decreased markedly by the application of ascorbic acid and ferrous ion.抄録全体を表示PDF形式でダウンロード (846K) -
丹野 慶紀, 佐々木 吉幸1974 年 94 巻 2 号 p. 221-224
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーEffect of difference in types of fillers on the homogeneity of the principal drug in triturations was examined by using fine phenobarbital labeled with 113mIn as the test drug. The test fillers were crystalline lactose with particle diameter in the range of 74-149 μ(I), fine lactose mixed it crystalline lactose (II), and corn starch mixed with fine lactose (III), each of which was used in preparing 10% 113mIn-phenobarbital powder. Mixing time was shortest with the test filler II. The mixture with the test filler I took the longest time to be prepared besides being not perfect. The degree of separation of 113mIn-phenobarbital by tapping was the highest in the mixture with III, and lowest in that with II. In the mixture with I or III, tapping decreased 113mIn-phenobarbital at the lower part of the vessel and its increase at the upper part, decrease in the lower layer being particularly marked. These results show that II, easily mixed with the principal drug and effective in maintaining its homogeneity, is the most suitable filler for trituration.抄録全体を表示PDF形式でダウンロード (692K) -
坂井 進一郎, 相見 則郎, 片野 清昭, 大平 裕美, 荻庭 丈寿1974 年 94 巻 2 号 p. 225-231
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーHydroxygardnutine (IV) was converted to gardnution (II), whose absolute configuration is known, by the route shown in Chart 2, and the configuration of Δ19 of IV has been clarified from this fact. The aldehyde (VII), derived from IV, gave abnormal reduction products (VIII and IX) by the Huang-Minlon method. The reaction is explainable by the mechanism (shown on Chart 4.) A similar treatment of compound XIII, formed from gardneramine (I), resulted in the formation of (19Z)-18-demethoxygardneramine (XIX)(as shown in Chart 7.) Difference in the chemical shifts of C15-H of natural (19E)-18-demethoxygardneramine (V) and XIX in their nuclear magnetic resonance spectra supports the above conclusion about the configuration of Δ19. NOE effect was observed between C18-CH3 and C15-H in compound (V) while there was no effect in XIX.抄録全体を表示PDF形式でダウンロード (950K) -
小泉 京子, 橋本 敬子, 御手洗 ミヤ子, 沢田 智加1974 年 94 巻 2 号 p. 232-237
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーIn diluted NaOH solution at 30°, glucose epimerized to fructose and mannose, and degraded to arabinose. Small amounts of ribulose, ribose and erythrose were also found in the degradation products. The degradation was affected by the concentration and volume of NaOH solution. When 2 mg of glucose was dissolved in 40 ml of 0.25 N NaOH, the yield of arabinose reached the maximum. Purity of the reaction solvent (water) had an effect on the yield of arabinose and therefore it was assumed that there were some catalyses by trace amounts of unidentified substance in water on the degradation. When Ba(OH)2 solution was used in place of NaOH solution, glucose was rather decomposed to non-carbohydrates. Utilization of the metabolic degradation of hexoses by commercial baket's yeast made a quantitative analysis of arabinose on the liquid chromatogram possible. Quantitation was accomplished by integrating the area under the peak using the height-width method, and it was found that 3.7% of glucose in 0.25 N NaOH solution degraded to arabinose after 27 hr. Autoradiogram of the transformation products from 14C-labeled glucose in 0.25 N NaOH solution indicated that the carbon in 1-position was split off to give arabinose.抄録全体を表示PDF形式でダウンロード (988K) -
三木 卓一, 平賀 謙太郎, 朝子 典彦, 吉岡 晃一, 杉原 弘貞, 中山 亮, 増岡 通夫1974 年 94 巻 2 号 p. 238-246
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーDi- and tri-methyl-substituted 19-nortestosterones were synthesized starting from 6-methoxy-4-methyl.(III) or 6-methoxy-4, 4-dimethyl-1-tetralone (IV) and 2-methyl (VIa) or 2-ethylcyclopentane-1, 3-dione (VIb). Among them the phenoxyacetate of d-6, 6-dimethyl-19-nortestosterone (XIIIb) showed a strong anabolic activity, whereas the antipode had no biological activity. The progestational activity of 6, 18-dimethyl-17α-ethynyl-19-nortestosterone (XXIVa) was 50 times that of ethisterone in the McPhail test (p.o.), but 6, 6-dimethylation of norethisterone did not increase the progestational activity.抄録全体を表示PDF形式でダウンロード (1288K) -
秋浜 澄行, 高橋 勝雄, 宮島 教子1974 年 94 巻 2 号 p. 247-251
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーThe inhibitory effect of bisbenzimidazole derivatives on poliovirus and adenoirus replication was investigated by the tube method. Among the compounds tested, 1, 3-bis(2-benzimidazolyl)propane (IV), 1, 3-bis(5 or 6-nitro-2-benzimidazolyl)propane (VI), 1, 3-bis(2-benzimidazolyl)-1, 2, 3-trihydroxypropane (VIII), 1, 4-bis(2-benzimidazolyl)butane (XII), 1, 4-bis(5 or 6-chloro-2-benzimidazolyl)butane (XIV), 1, 4-bis (5 or 6-methoxy-2-benzimidazolyl)butane (XVI), 1, 4-bis(2-benzimidazolyl)-1, 2, 3, 4-tetrahydroxybutane (XVII), 1, 4-bis(5 or 6-methoxy-2-benzimidazolyl)-1, 2, 3, 4-tetrahydroxybutane (XX), 1, 5-bis(5 or 6-methyl-2-benzimidazolyl)pentane (XXII), 1, 6-bis(5 or 6-methyl-2-benzimidazolyl)hexane (XXVI), 1, 6-bis(5 or 6-nitro-2-benzimidazolyl)hexane (XXVIII), and 1, 6-bis(5 or 6-methoxy-2-benzimidazolyl)hexane (XXIX) exerted a slight inhibition on the cytopathic effect of poliovirus, but did not show any antiviral activity against adenovirus. At the concentration of maximum nontoxic dose, IV, VI, VIII, XII, XVI, XVII, XX, XXII, and XXIX inhibited the plaque formation by poliovirus to 86.6%, 56.3%, 58.5%, 56.9%, 69.8%. 69.9%, 66.4%, 72.2%, and 65.6%, respectively. Compounds IV, XVI, XVII, and XXII also reduced the yield of intracellular virus and the incorporation of 14C-uridine into acid-insoluble material in HeLa cells infected with poliovirus.抄録全体を表示PDF形式でダウンロード (750K) -
難波 恒雄, 吉崎 正雄, 富森 毅, 小橋 恭一, 三井 健一郎, 長谷 純一1974 年 94 巻 2 号 p. 252-260
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーThe saponin patterns of ginseng and related crude drugs were investigated by quantitative thin-layer chromatography using a new apparatus equipped with a flame ionization detector. Hemolytic and its protective activities of these saponins were also determined in comparison with the saponin patterns. These chemical and biochemical data are considered to be useful for the evaluation of these crude drugs.抄録全体を表示PDF形式でダウンロード (1188K) -
亀谷 哲治, 竹下 光弘, 佐藤 文夫1974 年 94 巻 2 号 p. 261-264
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーA simple synthesis is described for hexadehydroyohimbane derivatives by the Mannich reaction of tetarhydro-β-carbolines, obtained by the Pictet-Spengler reaction of tryptamine with 3, 4-disubstituted phenylglycidates.抄録全体を表示PDF形式でダウンロード (634K) -
沢田 洋介, 谷山 兵三1974 年 94 巻 2 号 p. 264-266
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーβ-N-Acetyl-racemomycin-A, prepared by selective chemical reactions, exhibited a weak antimicrobial activity. This fact showed that β amino group of β-lysine in streptothricin antibiotics is an important site for exhibiting a biological activity.抄録全体を表示PDF形式でダウンロード (501K) -
吉名 重多賀, 田中 昭1974 年 94 巻 2 号 p. 267-270
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリー3-(p-Nitrophenyl)-2-oxo-1, 2-dihydrocinchoninic acid (III) was synthesized from isatin and 4-nitrophenylacetic anhydride, and derivatives of III with nitro group in paraposition of the benzene ring substituted with hydroxyl (XI), chloro (XII), and bromo (XIII) were prepared. Comparison of the reaction of these derivatives with thionyl chloride showed that in general only the hydroxyl in carboxyl group at 4-position was substituted with chlorine but, in the case of III, 2-position of the quinoline ring was also chlorinated besides the carboxyl group.抄録全体を表示PDF形式でダウンロード (603K) -
大沢 啓助, 上田 條二, 高橋 三雄1974 年 94 巻 2 号 p. 271-273
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーBesides lageracetal, n-amyl alcohol was isolated from the leaves of Lagerstroemia speciosa. The distribution of lageracetal, n-amyl alcohol, and ellagic acid in the leaves of Largerstroemia indica, L. subcostata, and L. fauriei was investigated. Ellagic acid was found in all these plants, while lageracetal was found in them except in L. fauriei, and n-amyl alcohol was found in these plants except L. subcostata.抄録全体を表示PDF形式でダウンロード (552K) -
今枝 一男, 栗木 武男1974 年 94 巻 2 号 p. 273-276
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーThe oxygen content of various inorganic and organic mercury compounds was determined by the Unterzaucher method. The tube filling was modified by packing porous silver at the tail of the tube where mercury vapor was trapped forming silver-mercury amalgam under a relatively low temperature. Organic mercury compounds containing nitrogen, sulfur, and chlorine were determined prebisely. Inorganic mercury compounds which were volatile at the temperature of the sample heater were also determined quantitatively, and mercurous chromate oxygen, except when it was left as chromium oxide, was determined. Total oxygen, however, could not be determined even if carbon powder was added on the sample. Even after the determination of oxygen was repeated about 100 times by the method using platinum carbon, no deterioration of platinum carbon was found.抄録全体を表示PDF形式でダウンロード (597K) -
上野 明, 白石 泰夫, 山本 俊之, 百木 克夫1974 年 94 巻 2 号 p. 276-279
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリー(±)-Phenyl-1-(imidazol-1-yl)-n-alkyl ketone-type compounds were prepared by the reaction of imidazole with (±)-phenyl-1-bromo-n-alkyl ketones. It was found that these compounds had high antifungal activity in vitro and antitrichophyton activity in vivo.抄録全体を表示PDF形式でダウンロード (637K) -
金庭 延慶, 高村 綱一1974 年 94 巻 2 号 p. 280-284
発行日: 1974/02/25
公開日: 2008/05/30
ジャーナル フリーAdsorption isotherms of a cationic surfactant, tetradecyltrimethylammonium bromide, on five kinds of sulfonamides, sulfadiazine, sulfaphenazole, sulfadimethoxine, sulfamonomethoxine, and sulfisomidine, from aqueous solution were determined at 30°. The isotherm of the surfactant on sulfisomidine illustrated a monolayer adsorption, and a multilayer adsorption on others. The amount adsorbed depended on the kind of sulfonamides, the amount adsorbed on sulfadiazine being the greatest and that for sulfisomidine the lowest. Further, it was suggested that both electrostatic and hydrophobic forces between sulfonamide and the surfactant were related to the adsorption. The porosity and redispersibility of a sedimentation bed depended not only on the amount adsorbed but also on the orientation of adsorbed molecules, and the relations between the amount adsorbed and porosity, and the amount adsorbed and redispersibility widely varied with the kind of sulfonamides. Especially, suspensions of sulfamonomethoxine showed a large specific sedimentation volume and easily redispersible sedimentation bed at all surfactant concentrations studied.抄録全体を表示PDF形式でダウンロード (683K)
- |<
- <
- 1
- >
- >|