The immunodepressive effect of RFP was examined by a method of rosette formation between guinea pig lymphocyte (GPL) and rabbit red blood cells (RRBC). The oral dose of 30mg/kg of RFP once every day for 12 days brought a serious immunodepression to the guinea pigs whose CMI was recovered during the term of above 2 months after thymectomy (named recovered guinea pigs) whereas it could not be detected in the guinea pigs whose CMI was still depressed due to the insufficient term after thymectomy (named immunodepressed ones). However, the depressive effect by the dose of 10mg/kg of RFP could not be detected. On the other hand, the influence by the dose of 30mg/kg of Sulfadimethoxine (SD) could not be detected either by the use of recovered guinea pigs or by immunodepressed ones. Since the dosage of DDS (20mg/kg) examined in the preceding report(⁸) about its immunodepressive effect on normal and recovered guinea pigs was too high to consider the effect on patients under DDS therapy, the influence of 5mg/kg of DDS on recovered guinea pigs was examined. However, in spite of positive result by Ghei, et al.(¹³) who noticed the immunodepression in volunteers by lymphocyte transformation method, the influence of DDS at the dosage of 5mg/kg could not be clearly noticed by this method. Along with these results, the discussions were made reference of the usage of this method, the attention to RFP and DDS therapies and the difference between DDS and SD.

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Effects of thalidomide on PMN chemotactic activity were investigated in guineapigs. Thlidomide, 12.5 and 25mg/kg, was injected intraperitoneally for two days, and in vitro chemotaxis of cardiac blood PMNs to LPS-treated serum and casein sodium was evaluated using Boyden chamber techniques. Thalidomide revealed no significant suppression of locomotion of PMNs.
It is suggested that the effect of thalidomide on erythema nodosum leprosum, an Arthus type reaction, is not caused by the reduced PMN chemotaxis in the peripheral blood.

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Since 1978, mass examinations for inpatients have done at Japanese National Lepro-sarium, Oshima Seisho-en.
This report describes about the data of the mass examination at 1978, especially the results about leprosy patients with abnormal urinary findings.
Numbers of those patients who underwent the mass examination and items of the examination are as follows:
Number of leprosy patients who underwent blood examination 288 patients
Items of blood examination CRP, GOT, GPT, ALP, Cholesterol, BUN, RBCC, WBCC, Hb
Number of leprosy patients who underwent urinalysis 303 patients
Items of urinalysis Haemacombistics (PH, urinary protein, occult blood, urinary suger, aceton) Urinary protein by sulphosalicylic acid method, Urobilinogen
The leprosy patients with abnormal urinary findings are divided into 5 groups as follows:
Group I; patients whose urinary protein was over 30mg/dl and erythrocyte count in sediment was 5 or more per 1 high power microscopic field: 16 patients
Group II; patients whose urinary protein test was negative or trace and erythrocyte count in sediment was 5 or more per 1 high power microscopic field: 17 patients
Group III; patients whose urinary protein test was over 30mg/dl and erythrocyte count in sediment was 4 or less per 1 high power microscopic field: 7 patients
Group IV; patients whose urinary protein test was negative or trace and erythrocyte count in sediment was from 4 to 1 per 1 high power microscopic field: 25 patients
Group V; patients whose leucocyte count in sediment was 10 or more per 1 high power microscopic field: 25 patients
After the mass examination, long term follow up was done to these leprosy patients with abnormal urinary findings except Group IV. Blood examination, urinalysis, urinary bacteriologic culture, IVP and clearance studies have been repeated many times.
Clinical diagnosis depending on the follow up studies are as follows:
Group I; 1) chronic glomerulonephritis: 6 patients
2) hepatic glomerulosclerosis: 1 patient
3) renal calculus: 1 patient
4) duplication of the pelvis with renal calculus 1 patient
5) chronic renal failure: 1 patient
Group II; 1) chronic glomerulonephritis 6 patients
2) Kimmelstiel-Wilson syndrome: 1 patient
3) hepatic glomerulosclerosis: 1 patient
Group III; 1) chronic glomerulonephritis: 1 patient
Group V; 1) perinephric abszess: 1 patient
2) diverticulum of the bladder: 1 patient
3) stricture of the urethra with prostatomegaly: 1 patient
4) urinary tract infection: 7 patients
These leprosy patients with renal complications are treated at Oshima Seisho-en and Leprosy Research Laboratory, Kyoto University School of Medicine.

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Comparative observations were made of the susceptibility of various inbred mouse strains (C3H, C57BL/6, DDD, BALB/c and KK) to intraperitoneal infection with avian tubercle bacilli, strain Kirchberg, concerning development of their visceral lesions, multiplication of the bacilli in the visceral organs and mean survival time of the infected mice.
Following intraperitoneal infection, the visceral lesions developed early in the KK strain and became so severe as to cause the ultimate death of the host, while in the C3H strain, the visceral lesions developed more slowly and remained still slight at the late stage of infection. The development of visceral lesions in the other strains was intermediate to that observed in these two, but much closer to the KK strain.
These mouse strain differences in the susceptibility are assumed to be mainly due to multiplication rate of the bacilli in the host.

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