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Volume 25, Issue 1-2
Displaying 1-12 of 12 articles from this issue
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Yoshiya HATA, Hiroshi MABUCHI, Yasushi SAITO, Hiroshige ITAKURA, Gensh ...1997 Volume 25 Issue 1-2 Pages 1-3
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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1997 Volume 25 Issue 1-2 Pages 4-12
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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1997 Volume 25 Issue 1-2 Pages 13-20
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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1997 Volume 25 Issue 1-2 Pages 21-25
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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1997 Volume 25 Issue 1-2 Pages 26-34
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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Shuji Tohda1997 Volume 25 Issue 1-2 Pages 35-38
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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Norihisa Matsuyoshi, Sadao Imamura1997 Volume 25 Issue 1-2 Pages 39-43
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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Ryuji Koik1997 Volume 25 Issue 1-2 Pages 45-51
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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Tetsuji Kobata1997 Volume 25 Issue 1-2 Pages 53-56
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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Noriharu Shijubo1997 Volume 25 Issue 1-2 Pages 57-62
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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Hiroshi YOSHIDA, Toshitsugu ISIIKAWA, Michio SUZUKAWA, Hideki SHIGE, K ...1997 Volume 25 Issue 1-2 Pages 63-66
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
JOURNAL FREE ACCESSAlpha 1-blockers (e. g., doxazosin, prazosin) are reported to have beneficial effects on plasma lipid and lipoprotein levels. We investigated the effect of naftopidil, a new alpha 1-blocker, on 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase and low density lipoprotein (LDL) receptor in cultured human skin fibroblasts in comparison with doxazosin. Naftopidil inhibited HMG CoA reductase activity and increased LDL receptor activity in a dosed-dependent manner. Doxazosin also inhibited HMG CoA reductase activity and increased LDL receptor activity. The changes in HMG CoA reductase and LDL receptor activity with naftopidil equal of approximately 10% of those changes obtained with doxazosin. Considering that the alpha 1-blocking property of naftopidil equals one-tenth of the blocking property of doxazosin, alpha 1-blockers seem to act on HMG CoA reductase and LDL receptor through the alpha 1-receptor.View full abstractDownload PDF (609K) -
[in Japanese], [in Japanese], [in Japanese], [in Japanese], [in Japane ...1997 Volume 25 Issue 1-2 Pages 67-70
Published: October 31, 1997
Released on J-STAGE: September 21, 2011
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