Journal of Intestinal Microbiology
Online ISSN : 1349-8363
Print ISSN : 1343-0882
ISSN-L : 1343-0882
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Volume 31, Issue 3
Displaying 1-3 of 3 articles from this issue
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  • Sleep and Intestinal Microbiota
    Junichiro IRIE, Hiroshi ITOH
    2017 Volume 31 Issue 3 Pages 143-150
    Published: 2017
    Released on J-STAGE: August 01, 2017
    DOIhttps://doi.org/10.11209/jim.31.143
    JOURNAL FREE ACCESS
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    The sleep-wake system is regulated by two processes: the sleep homeostasis and the clock-dependent alertness regulated by the central clock in the suprachiasmatic nucleus. Peripheral organs such as the intestine and liver are regulated by the peripheral clocks, and intestinal microbiota show diurnal oscillations in composition and function. Sleep disturbances due to jet lag or sleep deprivation disrupt microbiota diurnal oscillations, impact gastrointestinal tract function, produce dysbiosis, and drive metabolic disarrangements in the host. Regular feeding patterns can restore the diurnal oscillation of intestinal microbiota, promote entrainment to the central clock, and solve sleep disorders. Moreover, treatments with prebiotics and probiotics to improve sleep quality have been extensively investigated.
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  • Hypermutated Intestinal IgA Modulates Intestinal Microbiota towards Symbiosis
    Reiko SHINKURA, Shinsaku OKAI, Fumihito USUI
    2017 Volume 31 Issue 3 Pages 151-157
    Published: 2017
    Released on J-STAGE: August 01, 2017
    DOIhttps://doi.org/10.11209/jim.31.151
    JOURNAL FREE ACCESS
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    Dysbiosis of gut microbiota disrupts intestinal homeostasis and not only causes inflammatory bowel diseases but is also involved in other diseases. Intestinal IgA has been shown to shape the gut microbiota community. However, how secreted IgA regulates gut microbiota is not yet understood. We established hybridomas from intestinal lamina propria-derived IgA-secreting cells of wild-type mice, and identified the target bacterial epitope of intestinal IgA. Here, we describe one of the mechanisms by which intestinal IgA regulates gut microbiota.
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