Daniels' scalene lymphnode biopsy (SNB) was performed on 67 cases of clinically diagnosed sarcoidosis with typical BHL.
Lymphnodes were obtained in 60 cases, while typical noncaseating epithelioid cell granulomas were found in 44 cases. The positive rate of SNB, therefore, was 73.3% of the cases in which lymphnodes were obtained, and 65.8% in all the cases of the series.
The ratio of the SNB positive cases to the negative ones was analyzed regarding various items such as sex, age, previous history of tuberculosis, history of BCG innoculation, complaint, time span from diagnosis, history of steroid therapy, tuberculin reaction, Kveim test, prognosis after a year, amount of serum protien and gammer, globulin level, serum calcium and alkalin phosphatase level, degree of hilar and mediastinal lymphoadenopathy, presence of pulmonary and extrapulmonary lesions.
No difference was observed concerning the above items except the degree of mediastinal lymphadenopathy and the presence of pulmonary lesion. The positive rate of SNB was 86.7% in the cases with mediastinal lymphadenopathy sized more than 26mm in diameter, 71.4% in the cases between 16mm and 25mm, 75.0% in the cases less than 15mm and 36.8% in the cases without mediastnal lymphadenopathy; and 78.9% in the cases with pulmonary lesions and 48.3% in cases without the lesions.
The rate of radiological mediastinal lymphoadenopathy was higher in the SNB positive cases than in the negative cases, and the rate became higher with the extent of granulomatous changes seen in the scalene lymphnodes. In the cases with reticulosis, the rate was between in the cases with normal lymphnode and in the SNB positive cases.

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A number of recent studies seems to have reinforced the observation by Krogh and Lindhard in 1917 that the process of diffusion equilibrium is slow enough to leave a concentration gradient in the lungs, that is, stratified inhomogeneity.
This comes to an idea that the incompleteness of equilibrium would cause any detectable effect on gas transport.
Aim of the present study was to assess the significance of gaseous diffusion between inspired and alveolar gases in the lung.
When two different indicator gases are inspired simultaneously and the breath is held, the time course and/or the amount of gases which are transfered into pulmonary capillaries during a certain period of breath-holding will be different due to the difference in diffusivities of the indicator gases, if diffusion in the gaseous space is slow enough.
On the basis of this assumption and some theoretical considerations, experimental observations were made on 10 anesthetized dogs. Acetylene (C₂H₂) and monochlorodifluoromethane (CHClF₂) were chosen as indicator gases, which had different diffusivities and practically the equal solubilities in blood.
During breath-holding for 15 seconds at end-inspiration of a known volume of test gas, which contains approximately 1.5% of each indicator gas, respectively, six successive arterial blood samplings were made anerobically. Blood and gas samples were analyzed for C₂H₂ and CHClF₂ by gas chromatography, using Porapak-N column. Arterial gas contents of each indicator gas corrected by the concentration in the inspired gas were plotted againstithe time scale of breath-holding to obtain the ratio of gas transport.
The results obtained show that the more diffusible gas, C₂H₂, appears in arterial blood faster and slightly higher in the concentration than CHClF₂ for the early part of breath-holding. When the ratio of gas transports of the two indicator gases was compared for the first 3 seconds after the initial appearance of C₂H₂ in blood, the transport rate of C₂H₂ exceeded that of CHClF₂ by 10 to 17% on the average.
In conclusion, gaseous diffusion in the lungs cannot be disregarded as a factor of gas transport.

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[in Japanese]

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