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[in Japanese]

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Aim: The aim of this study was to clarify the usefulness of V CRESC α^® (NUTRI: Yokkaichi-shi,Japan), which is accessorial beverage contained trace elements and anti-oxidative vitamins.
Material&Method: Tweleve postoperative patients with biliary atresia (BA) orally ingested V CRESC α^® according to the Nutritional requirements for Japanese people for three months. Serum Manganase-Super Oxide dismutase (Mn-SOD) level was thought to be a good marker reflecting oxidization stress in the patients with chronic impaired liver function. The patients with BA were divided into two groups according to their serum Mn-SOD levels (HG: high value groups, NG: normal value groups).
Result: Serum Selenium (Se) levels of both groups were shown below normal levels before V CRESC α^® ingestion. After V CRESC α^® ingestion, serum Se levels were significantly improved to the normal range. In the HG, urine 8-Isoprostane levels and serum IGF-1 levels were significantly improved after V CRESC α^® ingestion. TypeIV collagen and liver function markers such as ALT, AST, etc. were not significantly improved after ingestion.
Conclusion: This study suggested that ingestion of the accessorial beverage containing trace elements and anti-oxidative vitamins in the postoperative patients with BA might be useful to reduce their severe oxidative stresses in their cell membranes.

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Purpose: Fucoidan, a substance contained in seaweeds, has a wide range of useful biological activities, but the effects of acetyl fucoidan derived from Okinawa mozuku (Cladosiphon okamuranus TOKIDA) on cancer have not been investigated. In this study we evaluated the cancer-suppressing effects of acetyl fucoidan derived from Okinawa mozuku.
Material and Methods: As an animal experiment model, a model of implanted mouse colorectal cancer cells was used. Following the implantation of the cancer cells, the experimental subjects were given tap water (control) or water containing 5% acetyl fucoidan. Changes in the mean body weight over time were measured, and tumor volume was measured. After the excision of the tumor tissues, histochemical examination was used to investigate the infiltration of the tumors and the presence or absence of apoptotic cells.
Results and discussion: A statistically significant weight loss suppression effect was found in the fucoidan group, and tumor volume was statistically significantly reduced in the fucoidan group. Histochemically as well, tumor infiltration was found to be inhibited in the fucoidan group, and apoptotic cells were observed.
Conclusions: Acetyl fucoidan derived from Okinawa mozuku was found to induce apoptosis in cancer cells and suppress tumor growth.

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