Journal of Pharmaceutical Science and Technology, Japan
Online ISSN : 2188-3149
Print ISSN : 0372-7629
Volume 73 , Issue 1
Showing 1-20 articles out of 20 articles from the selected issue
Feature Articles: The Latest Evaluation Technologies That Support the Drug Discovery and Development
  • Mariko Takeda-Morishita
    2013 Volume 73 Issue 1 Pages 56-62
    Published: 2013
    Released: February 10, 2019

    Despite revolutionary progress on the large scale to make therapeutic biodrugs such as peptides and proteins, the effective and convenient non-invasive delivery of these therapeutics remains a major challenge. Oral delivery of peptides and proteins remains an attractive alternative to parenteral delivery, and has resulted in various attempts at delivery development. Buccal insulin and nasal calcitonin were successfully developed and they are already on the market in some countries. Pulmonary insulin is currently in the last stages of clinical development. This review summarizes the non-invasive technologies that are being developed and succeeding in commercialization. In addition, the trends on current technologies under development for biodrugs are commented on.

    Download PDF (482K)
Regular Article
  • Masunari Fushimi, Kenjirou Higashi, Kunikazu Moribe, Keiji Yamamoto
    2013 Volume 73 Issue 1 Pages 72-81
    Published: 2013
    Released: February 10, 2019

    We investigated various physical properties of granules composed of low-substituted hydroxypropylcellulose (L-HPC) and water-soluble drugs (caffeine anhydrous or ascorbic acid) prepared by wet granulation. The crystalline state of the drugs in the granules was evaluated using powder X-ray diffraction, differential scanning calorimetry, and attenuated total reflectance Fourier transform infrared (FT-IR) spectroscopy. Caffeine anhydrous showed a reduction in crystallinity that was dependent on the amount of purified water added as kneading liquid, while ascorbic acid was observed to be in an amorphous state with any amount of purified water. Deuterated samples of each drug showed decrease in the area of the amorphous OH band of L-HPC in the FT-IR spectra. These results suggested the possibility that both drugs interacted with OH groups of the L-HPC amorphous domain by wet granulation independent of the amount of purified water added. The rate of water vapor sorption by the granules was reduced dependent on the amount of purified water added. The rate of water vapor sorption was suppressed in the presence of drugs. It was considered that the interaction between the drugs and the OH groups of the amorphous domain of L-HPC interfered with water vapor sorption.

    Download PDF (951K)