Journal of Pharmaceutical Science and Technology, Japan
Online ISSN : 2188-3149
Print ISSN : 0372-7629
ISSN-L : 0372-7629
Volume 78, Issue 6
Displaying 1-21 of 21 articles from this issue
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  • Yukari Kakino, Subaru Hori, Yoshihiro Hishikawa, Kohei Tahara, Hirofum ...
    2018 Volume 78 Issue 6 Pages 317-327
    Published: 2018
    Released on J-STAGE: November 01, 2018
    JOURNAL FREE ACCESS

    Jellies for oral administration are generally considered to be a dosage form that is easy to swallow. However, it is difficult to adjust drug dosage and control elution properties, making it is very difficult to develop a product especially for infants. To solve this problem, we developed a dry jelly as a novel dosage form that is converted to jelly after adding water at the time of administration. Based on our previous research, we developed dry jelly granules for the purpose of dispensing to improve convenience in medical institutions and controlling the elution of the drug. Carr's flowability index in the wet granulation and dry granulation (D1 and D3) formulations, obtained in this study, was from 79 to 80. Using both granulation methods, it was possible to prepare granules with good flowability that are easy to handle in a medical institution. The resulting granules had enough stability to use practically as a formulation. Although it is difficult to control the elution properties of the drug in conventional jellies for oral administration, it was easily possible in the jellies prepared in this study. The resultant jellies prepared from the dry jelly granules have satisfactory physical properties that facilitate swallowing in people who have difficulty in swallowing and prevent suffocation in infants aged 7 to 8 months or more.

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