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Volume 70, Issue 1
Displaying 1-11 of 11 articles from this issue
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Ikuo MORITA2003 Volume 70 Issue 1 Pages 1-8
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSDownload PDF (3135K) -
Maki HENMI2003 Volume 70 Issue 1 Pages 9-18
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSASK 2/MAPKKK 6 was identified as a member of the MAPKKK family, which shares 45% amino acid identity with ASK 1/MAPKKK 5. In this study, the genomic organization and promoter of mouse ASK 2 were determined. ASK 2 gene spans approximately 12 kb and is comprised of 29 exons, flanked by 5' regulatory regions. Through comparison with ASK 2 cDNA variant clones, two splice variants were identified : a transcript lacking 24 bases encoding 8 amino acids was caused by disuse of exon 3, and another frameshifted transcript due to 4 bases deletion was produced by usage of the first 4 bases of exon 17 as a part of the splicing acceptor. Reporter plasmid analysis demonstrated that a promoter existed in the immediate upstream region adjacent to exon 1. Interestingly, the 5'-flanking region of the promoter possessed a strong suppressive element. These results suggest that expression of ASK 2 is regulated by multiple mechanisms.View full abstractDownload PDF (1540K) -
Toshiyuki SHINKI2003 Volume 70 Issue 1 Pages 19-31
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSThe three-dimensional displacements of abutment teeth in fixed partial dentures (FPDs) during mastication were measured while changing the pontic occlusal design, for comparison against those of natural teeth. The purpose of this study was to clarify the influence of pontic occlusal form on the displacements of the abutment teeth, and to decide the optimum pontic occlusal design.
Three subjects, who each had a single missing tooth (upper first molar or second premolar), were chosen. After 3-unit FPDs were cemented, abutment tooth displacement during mastication was measured using a three-dimensional tooth displacement transducer Type M-3. The functional or non-functional cusp inclination of the pontic was changed gradually.
The flatter the inclination of the functional cusp of pontic became, the more the abutment teeth displaced in the buccal direction. The flatter the inclination of pontic non-functional cusp became, the less the abutment teeth displaced in the buccal direction, and the more the abutment teeth mostly displaced in the palatal direction.
If the inclination of the functional cusp of pontic becomes excessively flatter, or the inclination of pontic non-functional cusps becomes as steep as the natural teeth, non-physiological distortion may occur in periodontal tissues of the abutment teeth.View full abstractDownload PDF (3843K) -
Atsushi OHYAMA, Yoshinori TORIYAMA, Yoshiyuki SASAKI, Izumi KOYAMA, Ch ...2003 Volume 70 Issue 1 Pages 32-39
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSThe purpose of this study was to investigate the level of oral health awareness, and to explore the needs for home care workers to provide oral health care for disabled elderly. We conducted a questionnaire survey at two home-help service centers and a social welfare council. Subjects for this investigation were 63 home care workers.
The results were as follows:
1. Ninety-six percent of home care workers thought it was necessary to provide oral health care for disabled elderly, but only 11 percent of them put oral care into practice on a daily basis.
2 . From the results of a cause and effect diagram, necessities of oral care were summarized as six major causes : 1) Disabled elderly are often unable to brush their teeth, 2 ) The oral hygiene level may affect physical condition, 3 ) Disabled elderly should be protected from oral diseases, 4 ) Disabled elderly should have their mouths kept clean, 5 ) Eating and swallowing may become increasingly difficult, 6 ) Disabled elderly should take in adequate nutrition.
3 . Sixty-eight percent of home care workers took part in a training course of nursing care including oral care.
4 . Home care workers, dentists, dental hygienists, and nurses taught oral health care to home care workers.
5. From the results of a cause and effect diagram, there were three major items that home care workers want to know : 1) denture management, 2 ) the routine of oral care, 3 ) infection control.
6 . Home care workers recognized that oral care should be provided by family members of disabled elderly or home care workers.View full abstractDownload PDF (1201K) -
Nobuo NAKANISHI2003 Volume 70 Issue 1 Pages 40-45
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSProteoglycans with glycosaminoglycan side chains are found on the cell surface and in the extracellular matrix. Recently, it has been demonstrated that they are widely distributed in invertebrates, as well as in vertebrates. In the fruit fly, Drosoplaila melanogaster, core proteins of heparan sulfate proteoglycans (HSPGs), including division abnormally delayed (dally), dally like, perlecan, and syndecan, have been identified by genetic analyses. Biochemical studies of the glycosaminoglycan structure in Drosophila have also found the presence of chondroitin sulfate, in addition to heparan sulfate ; however, its core protein remains to be identified. Functional studies of HSPG in Drosophila have shown that dally and dally-like (members of glypican) are required for Wingless (a member of the Wnt family) signaling, and they are also implicated in affecting signaling of Decapentaplegic (a member of the transforming growth factor-/3/ bone morphogenetic protein superfamily) . Further evidence that HSPGs play important roles in these cellular signaling processes has been established from studies of genetic mutants defective in biosynthetic enzymes of HSPGs, such as sugarless (a homologue of UDP dehydrogenase), sulfateless (a homologue of HS N-deacetylase/N-sulfotransferase), and tout-vela (a homologue of Ext encoding HS polymerase) .
In this paper, the metabolism of Drosoplaila HSPGs was investigated to further clarify their biological functions, in two Drosoplaila cell lines : S 2 cell and Kc cell, using metabolic labeling techniques in combination with various pulsechase protocols.View full abstractDownload PDF (2118K) -
[in Japanese], [in Japanese]2003 Volume 70 Issue 1 Pages 46
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSDownload PDF (171K) -
[in Japanese], [in Japanese], [in Japanese]2003 Volume 70 Issue 1 Pages 47
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSDownload PDF (196K) -
[in Japanese], [in Japanese]2003 Volume 70 Issue 1 Pages 48
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSDownload PDF (170K) -
[in Japanese], [in Japanese], [in Japanese]2003 Volume 70 Issue 1 Pages 49
Published: March 31, 2003
Released on J-STAGE: December 08, 2010
JOURNAL FREE ACCESSDownload PDF (2102K) -
[in Japanese], [in Japanese], [in Japanese]2003 Volume 70 Issue 1 Pages 50
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSDownload PDF (2258K) -
2003 Volume 70 Issue 1 Pages 51-62
Published: March 31, 2003
Released on J-STAGE: October 08, 2010
JOURNAL FREE ACCESSDownload PDF (2123K)
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