[in Japanese]

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Alzheimer’s disease（AD）and frontotemporal dementia（FTD）are two different type of neurodegenerative dementia, which can cause aphasic symptoms. Problems in memory, visuospatial are the predominant symptoms in AD, while behavioral and language manifestations are core features in FTD. There have been many changes is concept and history of primary progressive aphasia （PPA）, recent studies have divided the syndromes into three subtypes based on type of aphasia, distribution of atrophy, and underlying histopathology :（i）nonfluent variant PPA ;（ii）semantic variant PPA ; and（iii）the logopenic variant of PPA. Relationship between neurodegenerative dementia and PPA provides us a unique window into brain-behavior relations.

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Some subjects withprimary progressive aphasia（PPA）, which is defined by a progressive loss of language ability, develop new artistic behaviors in the course of their disease. We had reported increased creativity in visual art, music and mechanical design in patients with PPA as they lose verbal language abilities. We believe that it reflects their underlying brain mechanism ; left-sided and frontal activities would inhibit right-sided and posterior functions, and new artistic ability was most notable in patients who had left-frontal disease withintact right-posterior and dorsolateral-medial frontal cortex. Our models of neurodegenerative disease may reflect premorbid developmental differences possibly predisposing subjects towards different ways of expression. Subjects showing relative strengths in some network reveal a relative vulnerability to unique neurodegenerative disease.

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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[in Japanese]

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