Cognitive reserve refers to an individual’s potential ability to suppress cognitive decline under the influence of brain pathology and aging. This cognitive reserve is related to previous education, work, leisure activity experience, premorbid intelligence, etc., and is expected to affect the function from the onset of various psychiatric and neurological disorders. It is important for medical professionals to keep such individual backgrounds and qualities in mind when considering the diagnosis and treatment of patients, the prospect of prognosis, the possibility of rehabilitation, etc. We are developing a clinically useful cognitive reserve evaluation method for Japanese people by applying it to a wide range of age groups and are also examining cognitive reserve for psychiatric and neurological disorders. We investigated the effect of cognitive reserve on cognitive function after tumor removal in patients with brain tumors. The results showed that damage to the superior longitudinal fasciculus affected the decline in working memory after surgery, and the higher the complexity of work, the less likely it was that the working memory would decline after surgery. Accumulation of cognitive activity is a factor that enhances cognitive reserve and may have acted protectively against the decline in working memory after brain tumor removal surgery.
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