Effects of volatile general anesthetics, halothane, isoflurane and enflurane, on γ-aminobutyric acid (GABA)-induced Cl^- current of rat dorsal root ganglion neurons in primary culture were studied by the whole-cell patch-clamp technique. Bath application of 0.3 mM GABA produced a peak current that decayed to a lower steady-state level due to desensitization. At surgical concentrations, all three anesthetics accelerated the current decay following the peak and suppressed the subsequent steady-state current, indicating that these anesthetics enhance desensitization of GABA receptor-Cl^- channel complex.
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