［目的］原因不明の慢性炎症性眼疾患であるのぶどう膜炎に対する30年間の診療経験をもとに，本疾患に対する漢方治療の意義について考察する。
［症例］過去30年間で漢方治療を求めて受診したのぶどう膜炎症例24例について検討した。
［結果］24例中11例は数ヵ月以内で通院しなくなり，十分な治療はできなかった。また，2例は患者の理解が十分に得られず転医を勧めた。しかし，11例は長期にわたって治療を行うことができ，3例を除いて，ほぼ正常の視力に回復し漢方治療の効果を確認できた。
［考察］のぶどう膜炎に対して継続的に漢方治療を行うことで再燃を抑えることができる可能性が示唆された。経過が順調であっても種々の誘因によって再燃することもあるが，廃薬にまで持って行ける可能性も大いにあることもわかった。ただし，現在までの経験から漢方治療の効果の確認には10年以上経過を観察することが必要であると思われる。
［結語］漢方治療はのぶどう膜炎の再燃防止に有効である。

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Pathological changes of venules and capillaries and perivascular infiltration with white cells suggestd participation of lysosomes in pathogenesis of Behcet's syndrome and kinetics of lysosomal enzymes in Behcet's syndrome were studied.
Activities of cathepsin D, acid phosphatase and β-glucronidase in serum, which were lysosomal marker enzymes, were determined with bovine hemoglobin, p-nitrophenyl phosphate and p-nitrophenyl glucronide respectively as their matrices. With β-glucronidase the activities were significantly higher in patients with Behcet's syndrome than normal controls (p<0.05), and especially, higher values were detected in acute stage than quiet stage (p<0.05) .
A serum factor which determines the labiability of the lysosomal membrane was examined as a causative factor of pathological kinetics of lysosomal enzymes. Rat liver lysosomal fraction was incubated with test sera and activities of released β-glucronidase were determined. Lysosomal membrane-labilizing ratio was defined as the percentage of released activity to the total activity of the fraction. The activities of thermolabile lysosomal membrane-labilizing serum factor, detected predominantly in the albumin fraction, were prominantly elevated in some patients with Behcet's syndrome compared with normal controls.
Studies of lysosomal enzymes in Behcet's syndrome will serve promising roles in exploring pathogenesis but also in establishing diagnosis and treatment.

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