35 patients with medial osteoarthritis of the knee underwent at random either a dome osteotomy (Dome) or hemicallotasis open-wedge osteotomy (Hemi). At one year after the operation, we compared the radiographic changes in the patellar tendon length, tibial plateau angle, and lateral shift of the proximal tibial plateau with respect to the tibial axis between the Dome group consisting of 20 knees of 18 patients and the Hemi group consisting of 19 knees of 17 patients. No significant differences were seen in the age, gender, femorotibial angle before and after the operation, and correction angle between the two groups. In the Dome group, the patellar tendon length became shorter, and the tibial plateau angle decreased significantly than that in the Hemi group without any changes. The degree in the lateral shift of the proximal tibial plateau in the Dome group was significant greater than the Hemi group. The results in this study showed that hemicallotasis open-wedge osteotomy shows little technical difficulties in the subsequent total knee arthroplasty seen after the dome operation, because there are no changes in the patellar tendon length and less deformity of the proximal tibial with respect to the tibial axis postoperatively. These slight changes are considered an advantage of this method.

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The mouse super-immunized with live vaccine of Salmonella enteritidis resisted intravenous injection of 1, 000 MLD of the same organism (Japan. J. Exp. Med., 30, 375-384). This anti-lethal resistance of mouse against the infection with S. enteritidis lasted for 16 months after the last injection of live vaccine (Japan. J. Exp. Med., 31, 187-190). The mononuclear phagocytes obtained from abdominal cavity, liver or subcutaneous tissue of mouse super-immunized with live vaccine did not allow the intracellular multiplication of bacteria regardless of the presence of antibody in the cell culture medium, whereas the cells obtained from normal mouse or the mouse immunized with dead vaccine did not (J. Bacteriol., 81, 863-868; J. Bacteriol., in press).
This paper deals with the appearance and duration of cellular immunity of mouse when immunized with live vaccine of S. enteritidis. The mononuclear phagocytes were obtained from the abdominal cavity of mouse immunized with live vaccine of S. enteritidis and were maintained in cell culture for in vitro infection. It was found that the cells obtained from the mouse 3 weeks after immunization resisted the degeneration caused by intracellular multiplication of bacteria. Even after 13 months of the last injection of live vaccine the cells did not allow the intracellular multiplication of bacteria regardless of the presence of antibody in the cell culture medium.

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