From the fronds of Polystichum tripteron (KUNZE) P_R. a new norcarotenoid glycoside was isolated and shown to be (6R, , R)--hydroxy-megastigma-, -dien--one--O-β-D-glucoside. The fronds of Dennstaedtia wilfordii (MOORE) CHRIST. contain the same glucoside.

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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Nアルキル,:,10-ペリレンテトラカルボン酸モノアンヒドリド=モノイミド[a～]と芳香族アミン(アニリン,p-トルイジン,p-アニシジン,,5-キシリジン,-アミノナゾベンゼン,およびo-フェニレンジアミン)を縮合して非対称型,:,10-ペリレンビス(ジカルボキシミド)誘導体-N-アルキル-N'-アリール-,:,10-ペリレンビス(ジカルボキシミド)(〔5a～〕,〔6a～〕,〔a～〕,〔8a～〕,〔a～〕,および〔10a～〕)を合成した. これらの各誘導体はすべて赤色系の色相を示し, 顔料試験の結果N-ブチル-N'-アリール-,:,10-ペリレンビス(ジカルボキシミド)(たとえば〔5〕や〔6〕)がとくにすぐれた耐光性を示した.

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The association between apolipoprotein (Apo-) polymorphism and the response of plasma cholesterol to dietary therapy (cholesterol intake of less than 300mg/day) was investigated for about 8 weeks in 208 nonfamilial hypercholesterolemia patients (/ 161, / 47). The baseline lipoprotein concentration and the intake of energy and lipids were not significantly different between subjects with / and those with / phenotypes. After the dietary therapy plasma total cholesterol and low density lipoprotein cholesterol were significantly decreased in both phenotype groups (p<0.05). The patients with / had significantly smaller reductions of LDL-C than the patients with /. The changes of LDL-C showed a significant difference between the patients with / and / by the Kruskal Wallis test (p=0.041). The presence of / predicted the degree of cholesterol reduction following dietary therapy.

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Background

The differences in conditions of enteric-coated acid-labile drug release and absorption between healthy subjects in bioequivalence studies and gastrointestinal patients in clinical practice can lead to significant differences in gastric stability of original PPIs and generics. Thus, pathologic duodenogastric reflux (PDGR) and the pH increasing within PPIs administration still remain unaccounted for.

Methods

Two-stage modified comparative dissolution testing of original omeprazole (OO) and four generics (G1;2;

;) was performed. At first, we moved drugs from solution with pH 1.2 (1.2±0.05) to pH .0 (.0±0.05) and measure concentration of omeprazole in solution by high-performance liquid chromatography. According to our self-developed formula, pH exposure time of resistance to PDGR for omeprazole is minutes, i.. the active substance should not be released within minutes at pH . The exposure at the second stage was conducted with pH (.0±0.05), that imitated gastric pH after PPI administration. And then we also moved drugs to pH with the subsequent measurement of omeprazole concentration.

Results

Omeprazole concentrations after

, 10, 15, 20, 30, 45, 60 minutes in pH solution at the first stage were different for OO and generics. For OO, these values were ,±0,%; 41,±,0%; 62,8±,0%; 79,5±2,%; ,5±2,%; 81,6±2,%; 80,6±,%; for Generic1 - 0; 49,±,%; 88,8 ±2,8%; 90,±,%; 88, 2±2,2%; 87,±2,0%; 85,±1,1%; for Generic2 - 0; 30,6±6,%; 66,±8,2%; 76,±,%; ,8±5,%; 86,0±,%; 84,6±,%: for Generic - 80,8±,6%; ,5±1,%; , 8±,2%; ,±2,%; 81,±2,1%; ,1±2,0%; ,0±2,%; for Generic - ,5±1,%; 84,±0,8%; 84,2±1,2%; , ±0,%; ,±0,%; ,±0,%; ,8±1,1%, respectively.

An analysis of the omeprazole concentration in pH

solution at the second stage revealed the following parameters after the same time: for OO - ,±0,6%; 40, 5±,0%; 62,8±2,0%; 80,0±,1%; 85,±2,%; ,8±,%; 80,±,5%; for Generic1 - 0; 67,0±,8%; 89,±2,%; 91, ±,%; 89,1±1,6%; 88,±1,%; 87,8±1,2%; for Generic2 - 0; 42,2±5,6%; 75,1±,%; 81,0±6,0%; 88,±,2%; 88, 6±1,%; 87,±1,0%; for Generic - 85,5±0,5%; 85,6±0,5%; 84,±0,%; ,±,0%; 84,±0,%; 84,±0,%; 84,±0,%, respectively. Generic release and degradation were completely realized at pH .

Conclusion

Decreased gastric stability of Generic

and Generic makes PDGR and inhibited gastric acid secretion due to PPIs administration the potential causes of decreased enteric-coated acid-labile drugs stability.

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(6,)-2,-エポキシ-,,11,11-テトラメチルシクロウンデカ-6,-ジエン(2)をフムレン1((2,6,)-,,11,11-テトラメチルシクロウンデカ-2,6,-トリエン)より合成する既知の合成法は実際に牧率が低く合成的に問題がある.さらに,2の合成はその反応性や物性の研究のために簡単に高牧率で行われることが望まれる.今回,2の新たな合成法と簡便な精製法を見いだし,2を高牧率で1から合成することができたので報告する.1のジエポキシ化,続く再結晶により得られたジエポキシド(8)は二価のチタンにより還元されて,1(273%)と8(25%)と少量のを含む2を主生成物(42.%)として与えた.1とは原料として再利用できる.2の精製は1と同様硝酸銀()錯体の結晶で行い,純粋な2は1から通算牧率32.0%で得られた.2の既知方法による合成は段階の反応と数回のカラム分離及び10%含浸シリカゲルカラム分離を必要とし牧率が極端に低い.今回,新しい2の合成法は2段階の反応で1回のカラム分離と再結晶により高い通算牧率を示す.

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.

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This paper applies the fuzzy cluster analysis to six international stock markets (i.., France, Germany, the U.S., Canada, Japan, and China). We analyze the similarity values calculated from the monthly stock returns, using both Zadeh's and Ward's clustering methods. These two methods induce different partition trees. Both the Minkowski distance and cophenetic correlation coefficient choose Zadeh's method over Ward's method. The optimal partition tree and the associated optimal number of clusters suggest (1) the similarity of European countries, (2) the institutional regularity of the Chinese stock market, and () the strong influence of the U.S. These implications are consistent with standard economic theory, and are preserved under the addition of three countries (i.., the U.K., Mexico, and South Korea).

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-(2-Aminophenylthio)-, 6-dichloropyridazine (I) on treating with dil. Hydrochloric acid or acetic acid gave -chloro-5H-benzo[]pyridazino[, -][1, ]thiazine (, -diazapheno-thiazine type) through rearrangement and cyclization. -Chloro-10H-benzo[]pyridazino-[, -][1, ]thiazine (1, 2-diazaphenothiazine type) was obtained by either heating of I at 150°or treating of I with conc. hydrochloric acid through direct cyclization. The mechanism of the aforesaid reactions was discussed using a molecular orbital method. Several 1, 2-and , -diazaphenothiazine derivatives were synthesized.

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The leaning tower of Pisa is a famous historical structure, especially in the field of soil mechanics. In this paper, the historical development of the inclination is reconstructed considering that a ground failure took place after each of the three construction phases. Model tests (scale 1 : 130) were carried out in order to predict that the tower will fail definitely, i.. without any further disturbances, at an angle of inclination of 5.°, which is dramatically close to the actual value of 5.5°. The estimated probability of failure rises very quickly with an increase in the angle of inclination. Conservation of the tower should be done therefore with utmost caution.

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The performance of single pitch and multi pitch screw anchors during the application of installation torque is presented. An experimental testing program was conducted using five models of screw anchors with different geometry. The effect of the shape of the screw element, sand properties, and installation depth on the required installation torque value was examined. A theoretical model was developed from which the required installation torque value can be calculated in terms of the influencing factors. The required installation torque can be determined in terms of the ultimate uplift resistance calculated from any of the available theories. Based on the actual installation torque value measured in the field, the anticipated pullout capacity can be back calculated from the present theory. A comparison between theoretical and experimental results showed good agreement. Also, good agreement was observed when the present theoretical results were compared with the available field results reported in the literature.

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

. coli isolates were detected in (.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), blaTEM-

1b

(42), bla_CMY-2 (

22

), blaCTX-M-

3

(16), bla_CTX-M-1 (15), bla_OXA-1 (

9

) and bla_SHV-12 (

3

) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.8%), followed by group D₂ (

22

.1%),

B

1 (15.8%), D₁ (

9

.5%), A₀ (

7

.

4

%),

B2₂

(5.

3

%) and

B2₃

(

4

.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.

3

, 10.5 and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.8% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing

E

. coli clone O25

b

:ST131/

B

2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing

E

. coli isolates among dogs in Turkey.

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Results of model loading tests on dense sand were reviewed to assess the variation in bearing capacity factors N_γ and N_q relative to the width of the foundation base. Consequently, it is confirmed that N_γ decreases non-linearly with increase in the width of foundation base and that N_q decreases more sharply than N_γ does as the width increase. It is also found that N_q decreases as the ratio of burried depth to the width increase. The cause of decrease in N_γ or N_q with increase in the width is regarded to be the rise of stress level which induces lowering of the angle of internal friction φ and volume reduction in the bearing sand by compression.

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In Japan, aseptic meningitis cases due to enterovirus infections increase every summer in various degrees with an incidence peak usually in July. During the past 11 years from 1981 through 1991, a total of 8, 595 enterovirus isolations from aseptic meningitis cases were reported from 54 participating laboratories. Eight enterovirus types caused large epidemics; more than 100 isolations of each type from aseptic meningitis cases were reported for every epidemic year of the respective type. They were coxsackievirus (C) types and 5, echovirus () types , 6, , , 18 and 30. Among these, the highest meningitisassociating frequency was reported for 30, representing .6% of the total isolations reported for the type during this period, followed by , 71.1%. The frequencies of , , 6 and CB5 were in a range from 54.5% to 44.%, while that of 18 was 37.% and that of CB 21.0%. During the epidemics, enterovirusassociated meningitis was most frequently reported among children of - years of age. High frequencies were also shown in infants less than 1-year of age in some types. A total of , 240 enteroviruses were isolated from cerebrospinal fluid of aseptic meningitis cases, representing 49.% of the cases with enterovirus isolation.

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