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  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • FRANÇOIS LE GOFFIC, FRÉDÉRIC TANGY, BERNARD MOREAU
    The Journal of Antibiotics
    1979年 32 巻 12 号 1288-1292
    発行日: 1979年
    公開日: 2006/04/12
    ジャーナル フリー
    A sample of [3H] tobrarnycin (
    5
    , 000 Ci/Mole) has been synthetized and incubated with
    the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
    two types of binding sites. The primary one is probably responsible for the inhibition of
    protein synthesis whereas the secondary one is probably related to the misreading and reading
    tiirough of the messenger RNA.
  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-3 (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.
    8
    %), followed by group D2 (
    22
    .1%),
    B
    1 (15.
    8
    %), D1 (
    9
    .
    5
    %),
    A0
    (
    7
    .4%),
    B22
    (
    5
    .3%) and
    B23
    (4.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.
    0
    % for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • 林 雄二, 松本 武
    天然有機化合物討論会講演要旨集
    1981年 24 巻 42
    発行日: 1981/09/10
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Reactions of nor-diterpenoid dilactones isolated from Podocarpus plants have been investigated. The
    7
    :
    8
    ,
    9
    : 11-dienolide type [
    C
    ] dilactones, the least available but biologically the most active members, are mainly derived from naturally abundant dilactone components of α-pyrone type [A] and
    7
    :
    8
    -epoxy-
    9
    : 11-enolide type [
    B
    ] for total-synthetic and biological purposes. From nagilactone
    E
    (
    5
    ), for example, a combined sequence of hydrogenolysis of
    7
    :
    8
    -epoxide group and dehydration gives nagilactone
    F
    (
    7
    ), 3β-hydroxynagilactone
    F
    (
    8
    ) and 2: 3-dehydronagilactone
    F
    (19), which have been found from natural sources. From nagilactone A (1), photo-hydration and concomitant double bond migration of its acetate results in a lactol (
    22
    ), which is reduced to 1β-hydroxynagilactone
    F
    (
    9
    ), another natural type [
    C
    ] dilactone. Derivation of the type [A] or [
    B
    ] from others is not successful. Some attempts for conversion of the ring A functional groups have also been studied.
  • 小林 優, 家坂 貴子, 中野 江身子, 平山 耕一郎
    天然有機化合物討論会講演要旨集
    1989年 31 巻 71/P2-1
    発行日: 1989/09/17
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Six new cembranoids sarcophytol P (3), R (4), S (
    5
    ), K (
    8
    ),
    F
    (11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (3) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (1), and afforded the cyclization product 6 in CHCl_3 at room temperature, in a same way as in 1. Sarcophytols R (4) and S (
    5
    ) were correlated to 1, by conversion of its
    7
    R,
    8
    R and
    7
    S,
    8
    S epoxide derivatives. Sarcophytol K(
    8
    ) was a 13, 14-dihydroxycembranoid having a 1
    E
    ,3Z-diene moiety. The absolute configuration of
    8
    and its 1Z,3
    E
    - and 1Z,3Z-isomers sarcophytol
    B
    (2) and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols
    F
    (11) and T (13) were 1
    E
    - and 1
    E
    ,3Z-isomers of 1. Compound 11 showed characteristic broadening of the ^1H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols
    F
    (11, 1
    E
    ,3
    E
    ), N (15, 1Z,3Z) and T (13,1
    E
    ,3Z), spontaneous autoxidation-cyclization, in CHCl_3,was examined, in order to compare the stereochemical course of the reaction with that of 1 (1Z,3
    E
    ), which affords trans-fused bicyclo[
    9
    .3.
    0
    ]tetradecene systems. The 1
    E
    ,3Z-isomer 13 gave the same cyclization product 18, as in the reaction of 1, even though it is isomeric at
    C
    -1,3. The 1Z,3Z isomer 15 gave 19, in consequence of the reversed geometry at
    C
    -3 of 15. The 1
    E
    ,3
    E
    -isomer (11) gave the bicyclic product
    22
    , having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and
    22
    , giving enantiomeric ketones 23 and 24 respectively. The 1(14)-epoxide 26 was shown to be the immediate precursor of
    22
    , and acounted for the inversion of the geometry at
    C
    -1 of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from 1. The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and
    22
    , was controlled by the chirality of the epoxy rings. The
    C
    -14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene
    C
    (30), the parent hydrocarbon of 1, also reacted in CHCl_3 giving the bicyclic product 32.
  • 香山 滉一郎, 森下 政夫, 張 国鋒
    粉体および粉末冶金
    2006年 53 巻 5 号 419-429
    発行日: 2006年
    公開日: 2006/12/19
    ジャーナル オープンアクセス
    The phase diagrams of the Ni-Mo-
    B
    and Ni-W-
    B
    ternary systems in the region of less than 50mol%
    B
    were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
    E1
    :L (1365K, 71.
    5
    mol%Ni-6.
    0
    mol%Mo-
    22
    .
    5
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiMo2B2

    E2
    :L (1355K, 62.
    5
    mol%Ni-2.
    5
    mol%Mo-30.
    5
    mol%
    B
    )=
    Ni3B
    +
    Ni2B
    +
    NiMo2B2

    E3
    :L (1445K, 42.
    0
    mol%Ni-30.6mol%Mo-10.3mol%
    B
    )=(Ni)+NiMo+
    NiMo2B2

    P1:L (1812K, 34.
    9
    mol%Ni-42.3mol%Mo-
    22
    .
    8
    mol%
    B
    )+MoB=
    Mo2B
    +
    NiMo2B2

    P2:L (1633K, 42.3mol%Ni-40.4mol%Mo-17.3mol%
    B
    )+Mo=
    Mo2B
    +
    NiMo2B2

    P3:L (1812K, 53.
    5
    mol%Ni-33.
    7
    mol%Mo-12.
    8
    mol%
    B
    )+Mo=NiMo+
    NiMo2B2

    E1
    :L (1622K, 51.
    0
    mol%Ni-31.6mol%W-17.4mol%
    B
    )=(Ni)+W+
    NiW2B2

    E2
    :L (1260K, 71.
    0
    mol%Ni-
    7
    .
    0
    mol%W-
    22
    .
    0
    mol%
    B
    )=(Ni)+
    Ni3B
    +
    NiW2B2

    E3
    :L (1291K, 65.4mol%Ni-4.
    8
    mol%W-29.
    8
    mol%
    B
    )=
    Ni2B
    +
    Ni3B
    +
    NiW2B2

    P1:L (2115K, 23.
    8
    mol%Ni-43.1mol%W-33.1mol%
    B
    )+WB=
    W2B
    +
    NiW2B2

    P2:L (1657K, 48.
    9
    mol%Ni-33.1mol%W-18.
    0
    mol%
    B
    )+
    W2B
    =W+
    NiW2B2

    The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
  • Yanchun Peng, Zitong Yu, Shahidul Islam, Yujuan Zhang, Xiaolong Wang, Zhensheng Lei, Kan Yu, Dongfa Sun, Wujun Ma
    Breeding Science
    2016年 66 巻 4 号 646-652
    発行日: 2016年
    公開日: 2016/09/30
    [早期公開] 公開日: 2016/08/11
    ジャーナル フリー HTML
    電子付録

    Low molecular weight glutenin subunits are important components of wheat storage proteins, which play an important role in determining end-use quality of common wheat. A newly established matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) procedure was used to analyze 478 landraces of bread wheat collected from the Yangtze-River region in China. Results indicated that 17 alleles at three loci: Glu-A3, Glu-

    B3
    and Glu-D3 were identified, resulting in 87 different allele combinations. Of the 17 alleles detected at all the Glu-3 loci, five belonged to Glu-A3, seven to Glu-
    B3
    and five to Glu-D3 locus. MALDI-TOF-MS indicated Glu-A3a/
    c
    was present in 72.
    8
    %, Glu-
    A3b
    in
    8
    .4%, Glu-A3d in
    8
    .4%, Glu-
    A3f
    in
    5
    .2% and Glu-
    A3e
    in 3.6% lines. Seven types of alleles were identified at the Glu-
    B3
    locus: Glu-
    B
    3d/i
    (25.
    5
    %), Glu-
    B3b
    (21.3%), Glu-
    B3c
    (16.
    9
    %), Glu-
    B3h
    (13.
    8
    %), Glu-
    B3f
    (
    8
    .4%), Glu-
    B3a
    (
    8
    .2%), and Glu-
    B3g
    (
    5
    .2%). Five types of Glu-D3 alleles were detected: Glu-D3a (58.4%), Glu-
    D3c
    (
    22
    .6%), Glu-D3d (15.
    5
    %), Glu-
    D3b
    (3.3%) and Glu-
    D3f
    (
    0
    .2%). Four new alleles that showed abnormal MALDI-TOF spectrum patterns were identified at the Glu-A3 and Glu-
    B3
    loci. A detailed study is needed to further characterize these alleles and their potential usage for wheat improvement.

  • 山本 雅史, Abkenar Asad Asadi, 松本 亮司, 根角 博久, 吉田 俊雄, 國賀 武, 久保 達也, 冨永 茂人
    園芸学会雑誌
    2007年 76 巻 1 号 36-40
    発行日: 2007年
    公開日: 2007/03/06
    ジャーナル フリー
    カンキツ主要12種を用いて染色体のクロモマイシン A3(CMA) 染色を行った.染色体は CMA(+) バンドの有無および位置から
    7
    種類に区分できた.すなわち,CMA(+) を A: 両端および動原体近傍に有する,
    B
    : 一方の端部と動原体近傍に有する,
    C
    : 両端に有する,D: 一方の端部に有する,
    E
    : CMA(+) がない,
    F
    : 動原体近傍に有する,Dst: 付随染色体を有する D 型,である.各種はこれらのうち 2~6 種類の染色体を有し,独自の CMA バンドパターンを示した.
    C
    . medica
    では 2
    B
    +
    8
    D +
    8
    E
    C
    . limon
    では 1
    B
    + 1
    C
    +
    8
    D +
    8
    E
    C
    . aurantifolia
    では 2
    B
    +
    9
    D +
    7
    E
    C
    . aurantium
    では 1A + 1
    B
    + 1
    C
    +
    7
    D +
    8
    E
    C
    . sinensis
    では 2
    B
    + 2
    C
    +
    7
    D +
    7
    E
    C
    . maxima
    では 3A + 3
    C
    + 4D +
    8
    E
    C
    . paradisi
    では 2A + 3
    C
    + 6D +
    7
    E
    C
    . ichangensis
    では 2
    B
    + 2
    C
    + 12D + 2
    E
    C
    . latipes
    では 2A +
    5
    C
    +
    8
    D + 3
    E
    C
    . micrantha
    では 1
    B
    + 11D + 4
    E
    + 2Dst,
    C
    . macroptera
    では 2
    B
    + 1
    C
    + 11D + 3
    E
    + 1
    F
    C
    . hystrix
    では 3
    B
    + 1
    C
    +
    8
    D + 3
    E
    + 2
    F
    + 1Dst であった.
  • Joey
    B
    . Tanney, Leonard J. Hutchison
    Mycoscience
    2012年 53 巻 1 号 31-35
    発行日: 2012年
    公開日: 2023/03/31
    ジャーナル オープンアクセス

    The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

  • 松藤 寛, ガン エン, 千野 誠, 合田 幸広, 豊田 正武, 武田 明治
    日本食品化学学会誌
    2002年 9 巻 3 号 107-113
    発行日: 2002/12/30
    公開日: 2017/12/01
    ジャーナル フリー
    市販食用緑色3号(主色素:HSBA-(m-EBASA)(m-EBASA)、m,m-G-3)に含まれる3付随色素(Sub-A、
    B
    E
    )を精製単離し、MSおよびNMRを用いて構造決定した。Sub-Aは主色素のエチル基の一つが脱離した化合物HSBA-(m-BASA)(m-EBASA)、Sub-
    B
    はp,p-G-3、Sub-
    E
    はo,p-G-3であった。以前報告した付随色素(Sub-
    C
    F
    、G、H)を含め、
    7
    つの付随色素の市販品(1社4製品)中の含量を測定したところ、色素中にSub-Aは
    0
    .45〜1.20%、Sub-
    B
    0
    .19〜2.60%、Sub-
    C
    8
    .49〜27.
    0
    %、Sub-
    E
    0
    .05〜1.52%、Sub-
    F
    は1.15〜2.37%、Sub-Gは
    0
    .05〜
    0
    .
    22
    %、Sub-HはND〜
    0
    .24%含まれていた。
  • Takeshi ITABASHI, Nobuko OGASAWARA, Koohei NOZAWA, Ken-ichi KAWAI
    Chemical and Pharmaceutical Bulletin
    1996年 44 巻 12 号 2213-2217
    発行日: 1996/12/15
    公開日: 2008/03/31
    ジャーナル フリー
    Three new azaphilone derivatives designated falconensins
    E
    5
    (
    5
    ),
    F
    (6), and G (
    7
    ) were isolated from the mycelium o Emericella falconensis, along with falconensins A (1),
    B
    (2),
    C
    (3), D (4), and H (
    8
    ), and three hopane-type triterpenes, zeorin (
    9
    ), hepane-
    ,
    22
    -diol (10), and hopane-6α,
    ,
    22
    -triol (11). The structures of
    5
    -
    7
    were confirmed by spectroscopic investigation and chemical correlations. The absolute stereochemistry of falconensins A (1) to G(
    7
    ) was also established.
  • Pankaj BANDHORIA, Vivek K. GUPTA, D. K. GUPTA
    Analytical Sciences: X-ray Structure Analysis Online
    2006年 22 巻 x91-x92
    発行日: 2006年
    公開日: 2006/05/18
    ジャーナル フリー
    (25R)-Spirost-
    5
    -en-3 β-acetate (
    C29H44O4
    ) crystallizes in monoclinic space group P21 with a = 14.559(2),
    b
    = 6.212(3),
    c
    = 14.847(
    7
    )Å; β = 100.
    22
    (2)°, Z = 2, Dcal = 1.148 Mg/m3. The structure was solved by direct methods and refined by full-matrix least-squares procedures to a final R-value of
    0
    .0513 for 2176 observed reflections. The six-membered A,
    C
    and
    F
    rings adopt the chair conformation, whereas rings
    B
    and D are in the half-chair conformation. Ring
    E
    is in the envelope conformation. The A/
    B
    ring junction is quasi-trans, while ring junctions
    B
    /
    C
    and
    C
    /D are trans fused about the
    C
    8
    -
    C
    9
    and
    C
    13-
    C
    14 bonds, respectively. The D/
    E
    ring junction is cis. The molecule is slightly convex towards the β side, with an angle of 10.
    7
    (2)°. Cohesion of the molecules in the unit cell can be attributed to van der Waals interactions.
  • 斎藤 徹, 井上 勲, 藤井 澄三
    Chemical and Pharmaceutical Bulletin
    1990年 38 巻 6 号 1536-1547
    発行日: 1990/06/25
    公開日: 2008/03/31
    ジャーナル フリー
    A full account is given of the chemical behavior observed for
    7
    ,
    9
    -dialkyladeninium salts (16). On treatment with boiling 1N aqueous NaOH for 60min, 16a,
    b
    , d,
    e
    (X=I), 16
    c
    (X=Br), and 16
    f
    (X=ClO4) rearranged to isomeric N6,
    7
    -dialkyladenines (21a-
    f
    ) in 50-91% yields. Treatment of the salts with
    0
    .
    5
    N aqueous Na2CO3 at room temperature for 30-90min or with Amberlite CG-400 (OH-) in H2O at room temperature gave the ring-opened derivatives
    22
    a-
    f
    (in the trans-formamide form) in 56-83% yields, and rate constants for the ring-opening reactions of 16a,
    b
    , d-g (X=ClO4) and 16
    c
    (X=Br) leading to
    22
    a-g were determined in H2O at pH
    9
    .84 and ionic strength
    0
    .50 at 25°
    C
    . Cyclization of
    22
    a with NaH in AcNMe2 at room temperature or with boiling 1N aqueous NaOH produced 21a in 84% or 72% yield, respectively.In solution, the trans-formamides
    22
    seemed to transform slowly into the cis-formamides 23, attaining equilibria. The existence of such an equilibrium in D2O or Me2SO-d6 at 25°
    C
    or in H2O at pH
    9
    .84 and ionic strength
    0
    .50 at 25°
    C
    was kinetically confirmed in the case of
    22
    a, and the mechanism of the rearrangement of 16 to 21 through
    22
    is discussed on the basis of the above kinetic results and Deslongchamps' theory of stereoelectronic control. On treatment with NaBH4 in MeOH at room temperature, 16a (X=I) furnished the
    7
    ,
    8
    -dihydro derivative 28 (84% yield), which slowly decomposed in H2O at 60°
    C
    to give
    22
    a in 49% yield.The
    7
    ,
    9
    -dialkyladeninium salts (16) were found to be obtainable from N'-alkoxy-1-alkyl-
    5
    -formamidoimidazole-4-carboxamidines (
    9
    ) through an alternative synthetic route : Alkylations of
    9
    with alkyl halides in HCONMe2 in the absence of base, followed by hydrogenolysis of the N'-alkoxy group and cyclizatio (or vice versa) produced 16 in acceptable yields. In order to interpret the proton nuclear magnetic resonance spectrum of
    22
    a, the 2-deuterated species 26 was also synthesized from 24 via 25 and 27.
  • ―特にアポ蛋白Eの変化について―
    本間 康彦, 三神 美和, 佐藤 美智子, 石原 仁一, 吉川 広, 木下 栄治, 田川 隆介, 星合 充基, 古屋 秀夫, 井出 満, 田辺 晃久, 玉地 寛光, 兼本 成斌, 友田 春夫, 中谷 矩章, 五島 雄一郎
    動脈硬化
    1984年 12 巻 3 号 599-603
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL2 and HDL3 were estimated on the
    0
    th,
    7
    th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II,
    E
    levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL2 and HDL3 were 15.
    9
    ±
    7
    .
    5
    mg/dl (mean±SD), 150.
    9
    ±58.1mg/dl 43.
    8
    ±
    9
    .6mg/dl, 16.4±
    5
    .
    8
    mg/dl and 24.
    9
    ±6.3mg/dl respectively. Plasma apoprotein A-I, A-II,
    B
    ,
    C
    -II and
    E
    levels were 81.
    7
    ±
    22
    .
    0
    mg/dl, 15.1±
    5
    .4mg/dl, 93.
    7
    ±36.
    0
    mg/dl, 3.83±1.00mg/dl and 4.29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
    C
    (r=
    0
    .348), HDL2-
    C
    (r=
    0
    .612) and HDL3 (r=
    0
    .569). Apoprotein
    B
    correlated with total cholesterol (TC) (r=
    0
    .610), VLDL-
    C
    (r=
    0
    .341), LDL-
    C
    (r=
    0
    .726), HDL-
    C
    (r=
    0
    .432) and HDL2-
    C
    (r=
    0
    .465). Apoprotein
    C
    -II correlated with TC (r=
    0
    .765), TG (r=
    0
    .679), VLDL-
    C
    (r=
    0
    .651), LDL-
    C
    (r=
    0
    .461) and HDL2-
    C
    (r=
    0
    .326). Apoprotein
    E
    correlated with TC (r=
    0
    .580), TG (r=
    0
    .575) and VLDL-
    C
    (r=
    0
    .666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=
    0
    .468). Apoprotein
    B
    correlated with apoprotein
    C
    -II (r=
    0
    .393). Apoprotein
    C
    -II correlated with apoprotein
    B
    (r=
    0
    .393) and
    E
    (r=
    0
    .549). Apoprotein
    E
    only correlated with apoprotein
    C
    -II (r=
    0
    .549).
  • Mohd Suhail, Mohd Faizul Suhail, Hina Khan
    Journal of Clinical Biochemistry and Nutrition
    2008年 43 巻 3 号 210-220
    発行日: 2008年
    公開日: 2008/10/31
    ジャーナル フリー
    We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
    B
    which comprised preeclamptics who were supplemented their diets with vitamins
    C
    and
    E
    . MDA increased from 6.
    22
     ± 2.
    8
    (placebo) to
    8
    .48 ± 1.2 (A) and
    8
    .02 ± 1.
    8
     nmol/gHb (
    B
    ). NO concentrations were enhanced from 19.3 ± 4.2 (P) to 23.
    8
     ± 6.4 (A) and 24.1 ± 
    5
    .4 μmol/L (
    B
    ). GSH contents were decreased from 10.42 ± 2.81 (P) to
    8
    .02 ± 2.92 (A) and
    9
    .39 ± 1.02 μmol/g Hb (
    B
    ), whereas GSSG concentrations increased from
    0
    .98 ± 
    0
    .28 (P) to 1.24 ± 
    0
    .29 (A) and 1.08 ± 
    0
    .12 μmol/g Hb (
    B
    ). SOD activity decreased 23% in A and 14% in
    B
    ; GRx decreased 27% in A and
    5
    .
    5
    % in
    B
    ; GPx decreased 12% in A and
    9
    .6% in
    B
    . Catalase activity, however, increased 27% in A and 29% in
    B
    as compared to control. Thus, we conclude that the use of vitamins
    C
    and
    E
    should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +
    C
    +D+K+aE+bF+cG. A^^〜=estimated values of the readership score. 1)
    B
    ,
    C
    , D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories.
    C
    =pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into 6 kinds of area (2.
    5
    , 3.
    5
    ,
    5
    ,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design. 3) a,
    b
    ,
    c
    : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(
    B
    +
    C
    +D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was 3,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is
    0
    .951. The table 2^* shows the contribution indexes of each factor by 3 kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (3) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _3+
    E
    _4. design elements [table]
    E
    _1,
    E
    _2,
    E
    _3,
    E
    _4, these values have the
    5
    grades, as
    0
    , 1, 2, 3, 4 and
    0
    is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of
    0
    to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades,
    0
    to 4. The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula.
    c
    ) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -4, and
    5
    -
    5
    in the thesis in Japanese.
  • 井原 正隆, 千尋 正利, 福本 圭一郎, 亀谷 哲治
    Chemical and Pharmaceutical Bulletin
    1984年 32 巻 1 号 373-376
    発行日: 1984/01/25
    公開日: 2008/03/31
    ジャーナル フリー
    Stereoselective synthesis of the 4,
    5
    -syn,
    5
    , 6-anti adducts (14 and 16) on the aldol condensation of the Z (O)-lithium enolate, derived from the
    E
    -enone (2), to α-alkoxy aldehydes (12 and 13) was proved via the successive intramolecular Diels-Alder reaction.
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