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  • Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori
    Biological and Pharmaceutical Bulletin
    2002年 25 巻 8 号 1040-1044
    発行日: 2002年
    公開日: 2002/08/01
    ジャーナル フリー
    We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC
    3
    T
    3
    -
    E
    1. Sixteen phosphate buffered saline (PBS), 8 boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC
    3
    T
    3
    -
    E
    1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
    22E
    ,24R)-ergosta-
    7
    ,
    22
    -diene-
    ,
    ,
    -triol (1). 1 induced ALP activities of MC
    3
    T
    3
    -
    E
    1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC
    3
    T
    3
    -
    E
    1 cells by 1, ergosterol (2), ergocalciferol (
    3
    ), cholesta-
    ,
    ,
    -triol (
    4
    ),
    7
    -dehydrocholesterol (
    5
    ) and cholecalciferol (
    6
    ) were tested. The enzyme activities of MC
    3
    T
    3
    -
    E
    1 cells were increased
    3
    .0-fold by 10 μM 1 and 2.
    4
    -fold by 10 μM
    4
    . However, 2,
    3
    ,
    5
    and
    6
    did not induce MC
    3
    T
    3
    -
    E
    1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at C-
    5
    and/or C-
    6
    of 1 and
    4
    played an important role in their differentiation-inducing activities on MC
    3
    T
    3
    -
    E
    1 cells. Furthermore, 1 suppressed induction of MC
    3
    T
    3
    -
    E
    1 cell apoptosis by serum starvation.
  • Joey
    B
    . Tanney, Leonard J. Hutchison
    Mycoscience
    2012年 53 巻 1 号 31-35
    発行日: 2012年
    公開日: 2023/03/31
    ジャーナル オープンアクセス

    The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

  • 財満 鎮雄, 竹内 洋一郎, 入交 裕
    軽金属
    1975年 25 巻 8 号 310-313
    発行日: 1975/08/30
    公開日: 2008/07/23
    ジャーナル フリー
    The modulns of longitudinal elasticity and their temperature dependence in commercial aluminum cast alloys were measured in the temperature range from room temperature (20°C) to 250°C by the resonant frequency method. The results obtained are as follows:
    The modulus of longitudinal elasticity tended to decrease weakly and linearly (the tangent of its decrease, m = (-2.
    4
    --
    3
    .
    3
    ) × 102kg/cm2/°C) with the rise of temperature. Within the range of the experiments, aluminum cast alloys were divided into
    3
    groups, the lst group materials having large moduli of elasticity
    E0
    at room temperature (i.
    e
    .,
    E0
    = (
    7
    .15-
    7
    .25) × 105kg/cm2) were
    AC
    2A-T
    6
    ,
    AC
    3
    A-
    F
    ,
    AC
    4
    A-
    F
    ,
    AC
    4
    A-T
    4
    ,
    AC
    4
    B
    -
    F
    ,
    AC
    4
    B
    -T
    4
    ,
    AC
    8A-
    F
    ,
    AC
    8A-T
    4
    , etc., the 2nd group materials having intermediate moduli (i.
    e
    .,
    E0
    = (
    6
    .85-
    6
    .98) × 105kg/cm2) were
    AC
    4
    C-
    F
    ,
    AC
    4
    C-T
    5
    ,
    AC
    4
    C-T
    6
    ,
    AC
    4
    D-
    F
    ,
    AC
    4
    D-T
    6
    ,
    AC
    7
    A-
    F
    , etc. and the
    3
    rd group materials showing considerably smaller moduli (i.
    e
    .,
    E0
    = (
    6
    .58-
    6
    .65) × 105kg/cm2) were
    AC
    1A-
    F
    ,
    AC
    1A-T
    6
    ,
    AC
    2A-
    F
    , etc. However, there were some differences between the moduli in this experiments and the moduli in the other data books, and these were considered due to the difference of the measurement principles and of hypotheses or assumptions involved in these principles, so it is suggested that the moduli of elasticity should be reported with indication of the measuring method.
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Shingo Nakamura, Tadahiro Hasegawa, Tsubasa Hiraoka, Yoshinori Ochiai, Shin’ichi Yuta
    Journal of Robotics and Mechatronics
    2018年 30 巻 4 号 540-551
    発行日: 2018/08/20
    公開日: 2018/08/20
    ジャーナル オープンアクセス

    The Tsukuba Challenge is a competition, in which autonomous mobile robots run on a route set on a public road under a real environment. Their task includes not only simple running but also finding multiple specific persons at the same time. This study proposes a method that would realize person searching. While many person-searching algorithms use a laser sensor and a camera in combination, our method only uses an omnidirectional camera. The search target is detected using a convolutional neural network (CNN) that performs a classification of the search target. Training a CNN requires a great amount of data for which pseudo images created by composition are used. Our method is implemented in an autonomous mobile robot, and its performance has been verified in the Tsukuba Challenge 2017.

  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • Takaaki ISHIZUKA, Yasunori YAOITA, Masao KIKUCHI
    Chemical and Pharmaceutical Bulletin
    1997年 45 巻 11 号 1756-1760
    発行日: 1997/11/15
    公開日: 2008/03/31
    ジャーナル フリー
    Four new sterols,
    ,
    -epoxy-(
    22
    E
    , 24R)-ergosta-8(14),
    22
    -diene-
    ,
    -diol (1), (
    22
    E
    , 24R)-ergosta-8,
    22
    -diene-
    ,
    ,
    ,
    -tetrol (2), (
    22
    E
    , 24R)-ergosta-
    7
    ,
    9
    (11),
    22
    -triene-
    ,
    ,
    -triol (
    3
    ) and
    ,
    ,
    -trihydroxy-(
    22
    E
    , 24R)-ergost-
    22
    -en-
    7
    -one (
    4
    ), have been isolated from the fruit bodies of Grifola frondosa (FR.) S.
    F
    . GRAY (Polyporaceae)together with fourteen known ones (
    5
    -18), of which two (
    5
    and
    6
    ) are reported for the first time from a natural source. The structures of these compounds were elucidated on the basis of spectral data.
  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +C+D+K+aE+bF+cG. A^^〜=estimated values of the readership score. 1)
    B
    , C, D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into
    6
    kinds of area (2.
    5
    ,
    3
    .
    5
    ,
    5
    ,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(
    B
    +C+D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by
    3
    kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _
    3
    +
    E
    _
    4
    . design elements [table]
    E
    _1,
    E
    _2,
    E
    _
    3
    ,
    E
    _
    4
    , these values have the
    5
    grades, as 0, 1, 2,
    3
    ,
    4
    and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades, 0 to
    4
    . The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -
    4
    , and
    5
    -
    5
    in the thesis in Japanese.
  • 村上 孝夫, 木村 毅, 和田 浩志, 田中 信寿, 斎木 保久, 陳 秋明
    Chemical and Pharmaceutical Bulletin
    1981年 29 巻 3 号 866-868
    発行日: 1981/03/25
    公開日: 2008/03/31
    ジャーナル フリー
    From the fronds of Polystichum tripteron (KUNZE) PR. a new norcarotenoid glycoside was isolated and shown to be (
    6
    R,
    7
    E
    ,
    9
    R)-
    9
    -hydroxy-megastigma-
    4
    ,
    7
    -dien-
    3
    -one-
    9
    -O-β-D-glucoside. The fronds of Dennstaedtia wilfordii (MOORE) CHRIST. contain the same glucoside.
  • Nobutoshi TANAKA, Ken-ichi HOSOI, Daizo TANAKA, Mimei TAKAHASHI
    Chemical and Pharmaceutical Bulletin
    1996年 44 巻 4 号 843-846
    発行日: 1996/04/15
    公開日: 2008/03/31
    ジャーナル フリー
    Chemical properties of ergosta-
    4
    ,
    6
    , 8(14),
    22
    -tetraen-
    3
    -one (1) were investigated. Though 1 is rather stable to acids or bases, it reacts easily with two moleculres of oxygen on irradiation with UV light to give
    ,
    -epidioxy-14α-hydroperoxyergosta-
    4
    ,
    7
    ,
    22
    -trien-
    3
    -one (2), which is transformed successively to
    ,
    ;8α,
    -diepoxy-14α-hydroperoxyergosta-
    4
    ,
    22
    -dien-
    3
    -one (
    3
    ) and 14α-hydroperoxy-
    -hydroxyergosta-
    4
    ,
    7
    ,
    22
    -triene-
    3
    ,
    6
    -dione (
    4
    ) under these reaction conditions.
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-
    3
    (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (
    3
    ) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.8%), followed by group D2 (
    22
    .1%),
    B
    1 (15.8%), D1 (
    9
    .
    5
    %), A0 (
    7
    .
    4
    %),
    B22
    (
    5
    .
    3
    %) and
    B23
    (
    4
    .2%), respectively. PMQR genes, aac(
    6
    ’)-Ib-cr, qnr
    S1 and qnrB10 were detected in 25.
    3
    , 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.8% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • JACINTO NEGRILLO, MANUEL NOGUERAS, ADOLFO SANCHEZ, MIGUEL MELGAREJO
    Chemical and Pharmaceutical Bulletin
    1988年 36 巻 1 号 386-393
    発行日: 1988/01/25
    公開日: 2008/03/31
    ジャーナル フリー
    Acetylation of
    4
    -(O-acetyl-β-D-glycopyranosylamino)-
    6
    -oxo-pyrimidines (2a, d,
    e
    ) with
    Ac2O
    /pyridine at
    80
    °C gave the
    6
    -acetoxy derivatives
    3
    a, d,
    e
    . Although these were also obtained by treatment with
    Ac2O
    /
    H2SO4
    , prolonged reactions of 2a-c,
    e
    -
    f
    gave the
    5
    -acetyl derivatives
    4
    a-c,
    e
    -
    f
    . The Vilsmeier reaction of 2
    b
    -g produced the
    5
    -formyl derivatives
    5
    b
    -g, whereas 2a gave the uracil derivative
    9
    under similar conditions.
  • Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE, Kiyomi KOBAYASHI, Suguru TAKATSUTO
    Agricultural and Biological Chemistry
    1988年 52 巻 8 号 2117-2118
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • T BAKER, C. RANGACHARYULU
    日本物理学会講演概要集
    1999年 54.2.1 巻 23pSM-6
    発行日: 1999/09/13
    公開日: 2018/03/04
    会議録・要旨集 フリー
  • 吉井 一郎
    日本臨床整形外科学会雑誌
    2017年 43 巻 1 号 1-9
    発行日: 2017年
    公開日: 2018/04/05
    ジャーナル 認証あり

    背景と目的:ステロイド性骨粗鬆症は,積極的な治療介入が必要とされる.その第一選択薬はビスホスホネート製剤(以下ビス)であるが,近年,デノスマブ(以下デノス)も注目を浴びている.ステロイド性骨粗鬆症の骨密度に対する両者の効果を比較検討した.

    方法:ステロイド性骨粗鬆症の管理と治療ガイドライン:2014年改訂版の薬物療法開始の基準を満たした患者を対象とした.無治療群(N群)と,治療介入群として当初よりビスで治療したBB群,ビス後デノスに変更したBD群,デノスで治療したDD群,デノス後ビスに変更したDB群を抽出し,ステロイド投与を開始した時,ステロイド性骨粗鬆症に対する治療を開始した時または薬剤変更から

    6
    カ月後の腰椎,大腿骨頚部と大転子部の骨密度を測定し,それらの変化を統計学的に比較検討した.

    結果:149例が抽出され,その内訳は,N群48例,BB群24例,BD群

    22
    例,DD群21例,DB群34例であった.治療開始時または薬剤変更から
    6
    カ月後にBD群を除くすべての治療介入群で腰椎の骨密度が上昇した.大腿骨の骨密度は,BD群において薬剤変更後に上昇に転じた.

    考察:デノスにはビスと同様の骨密度上昇効果があると考えられた.

    結論:デノスは,ステロイド性骨粗鬆症治療の第一選択薬となり得る.

  • A.M. BRITTO, C. SAVVIDOU, M.J. GUNN, J.R. BOOKER
    土質工学会論文報告集
    1992年 32 巻 1 号 13-25
    発行日: 1992/03/15
    公開日: 2008/02/29
    ジャーナル フリー
    One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.
  • 泌尿器科領域における臨床分離株と環境分離株に関する疫学的検討
    鎌田 日出男
    日本泌尿器科學會雑誌
    1979年 70 巻 10 号 1142-1158
    発行日: 1979/10/20
    公開日: 2010/07/23
    ジャーナル フリー
    1) P. aeruginosa has been consistently isolated from 26.
    5
    to 42.
    4
    % of the patients with urinary tract infections in the urological ward of Okayama University Hospital for the past
    7
    years. 232 (
    22
    .
    3
    %) out of 1042 hospitalized patients were with urinary tract infections with P. aeruginosa for past
    4
    years. Of these, 149 (64.2%) were thought to be the catheter induced urinary tract infections. The mode of spreading of this organism was epidemiologically investigated.
    2) The following three laboratory assays were used for identification of P. aeruginosa isolated from clinical and environmental strains; serological typing, antibiotic sensitivity and protease and elastase production. Serological typing with 13 immunodiagnostic sera (Toshiba Chemical Industry) was performed by slide agglutination method. Protease and elastase production were detected by the method described by Goto et al.
    In combination with serological typing and antibiograms, protease and elastase production offers the finest means of differentiating the strains of P. aeruginosa.
    3
    ) Of 136 clinical strains of P. aeruginosa, 89.
    7
    % were serotypable strains. Serotype K was the most prevalent (36.0%), followed by serotype
    E
    (28.
    7
    %),
    F
    (10.
    3
    %) and A (
    7
    .
    4
    %). Most of serotype
    F
    and
    B
    which were concurrently isolated from patients in 1976 had the same patterns of antibiogram and production of protease and elastase. It was strongly suggested that these patients were nosocomially cross-infected with the P. aeruginosa from the catheterization or through instrumentation.
    4
    ) Of 354 environmental specimens, 78 P. aeruginosa (
    22
    .8%) were isolated, which were frequently isolated from floor mops and sink-drains. Of these strains, 87.2% were serotypable strains. Serotype
    E
    was the most prevalent (42.
    3
    %), followed by serotype K (24.
    4
    %) and
    B
    (12.8%). The same strains were seldom detected at the same sources successively, but different types of P. aeruginosa were usually detected. Among the serotypes
    E
    ,
    F
    and K, 18 strains (23.1%) were identical with the clinical strains. All of these were found during or after the clinical outbreaks of P. aeruginosa infections. There was no environmental strains that caused clinical infections. The other 60 strains (76.
    9
    %) were different from the clinical strains, and present only transiently in the hospital environments.
    5
    ) Both clinical and environmental strains similary produced protease and elastase at 70 to
    80
    %, hemolysin at 100%. Only 10 out of 37 environmental strains (27.0%) were found to produced exotoxin.
  • Yukichi Yamaguchi, Jian-zhi Runan(Gen), Teruaki Nagahara
    Journal of the Physical Society of Japan
    1975年 38 巻 4 号 911-916
    発行日: 1975/04/15
    公開日: 2007/06/01
    ジャーナル 認証あり
    The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the 116mIn activity. Directional correlations are also measured for 818–1293 and 1097–1293 keV cascades. The M1-
    E
    2 mixing ratio δ, and the
    E
    0-
    E
    2 mixing ratio μk are obtained for 818.
    7
    keV
    22
    +→21+ transition to be δ=1.52
    0.22
    +0.26, and μk
    6
    .1×10
    4
    respectively. The
    E
    2 branching ratio
    B
    (
    E
    2;
    22
    +
    →0g+):
    B
    (
    E
    2;
    22
    +→21+):
    B
    (
    E
    2;
    22
    +→01+) is determined to be 0.0158:1.0:
    5
    .86.
  • 高津戸 秀, 池川 信夫
    Chemical and Pharmaceutical Bulletin
    1984年 32 巻 5 号 2001-2004
    発行日: 1984/05/25
    公開日: 2008/03/31
    ジャーナル フリー
    Brassinolide analogues, (
    22
    R, 23R, 24R)-2α,
    ,
    22
    , 23-tetrahydroxy-
    B
    -homo-
    7
    -oxa-
    -ergostan-
    6
    -one (24-epibrassinolide) (10) and (
    22
    S, 23S, 24R)-2α,
    ,
    22
    , 23-tetrahydroxy-
    B
    -homo-
    7
    -oxa-
    -ergostan-
    6
    -one (
    9
    ), were synthesized from brassicasterol (
    3
    a) in five steps and with ca. 20% overall yield. The key steps are the direct formation of (
    22
    E
    , 24R)-
    ,
    5
    -cyclo-
    -ergost-
    22
    -en-
    6
    -one (
    4
    ) from brassicasterol mesylate (
    3
    b
    ), the acid-catalyzed rearrangement of
    4
    to (
    22
    E
    , 24R)-
    -ergosta-2,
    22
    -dien-
    6
    -one (
    6
    ), and the Baeyer-Villiger oxidation of the tetrahydroxy
    -ergostan-
    6
    -ones
    7
    and 8.
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