Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL
2 and
HDL3
were estimated on the 0th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
B
, C-II,
E
levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL
2 and
HDL3
were 15.9±7.5mg/dl (mean±SD), 150.9±58.
1
mg/dl 43.
8
±9.
6
mg/dl, 16.
4
±5.
8
mg/dl and 24.9±
6
.
3
mg/dl respectively. Plasma apoprotein A-I, A-II,
B
, C-II and
E
levels were
81
.7±
22
.0 mg/dl, 15.
1
±5.
4
mg/dl,
93
.7±36.0mg/dl,
3
.
83
±
1
.00mg/dl and
4
.29±
1
.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-C (r=0.348), HDL
2-C (r=0.612) and
HDL3
(r=0.569). Apoprotein
B
correlated with total cholesterol (TC) (r=0.610), VLDL-C (r=0.341), LDL-C (r=0.726), HDL-C (r=0.432) and HDL
2-C (r=0.465). Apoprotein C-II correlated with TC (r=0.765), TG (r=0.679), VLDL-C (r=0.651), LDL-C (r=0.461) and HDL
2-C (r=0.326). Apoprotein
E
correlated with TC (r=0.580), TG (r=0.575) and VLDL-C (r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
B
correlated with apoprotein C-II (r=0.393). Apoprotein C-II correlated with apoprotein
B
(r=0.393) and
E
(r=0.549). Apoprotein
E
only correlated with apoprotein C-II (r=0.549).
抄録全体を表示