We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC3T3-1. Sixteen phosphate buffered saline (PBS), 8 boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC3T3-1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (,24R)-ergosta-,-diene-3β,,6β-triol (1). 1 induced ALP activities of MC3T3-1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC3T3-1 cells by 1, ergosterol (2), ergocalciferol (3), cholesta-3β,,6β-triol (4), -dehydrocholesterol () and cholecalciferol (6) were tested. The enzyme activities of MC3T3-1 cells were increased 3.0-fold by 10 μM 1 and 2.4-fold by 10 μM 4. However, 2, 3, and 6 did not induce MC3T3-1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at C- and/or C-6 of 1 and 4 played an important role in their differentiation-inducing activities on MC3T3-1 cells. Furthermore, 1 suppressed induction of MC3T3-1 cell apoptosis by serum starvation.

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The paper examines how well standard sources of impact sounds(bang-machine, A-ball, NF-ball, new rubber ball)imitate real impact sounds(human jumping and hopping).The compared sounds were described from psychoacoustic point of view.At the same time similarities between the impact sounds were judged in the psychoacoustic experiment.Results were compared with the existing standards expressed in F- and S-maximum sound levels:L_{A max, F}, L_{A max, S} and sound exposure level L_AE.

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The ability of Climacodon septentrionalis to immobilize and kill a mycophagous nematode (Aphelenchoides sp.) in vitro is described for the first time. Two isolates produced droplets (20–45 μm in diameter) that formed at the apices of tall, stalked, and branching secretory cells (700–1,500 μm tall). On 2% modified malt extract agar, nematodes became enveloped in the droplets, which restricted their ability to move and resulted in complete immobilization and death within several hours of contact. The rate of decomposition of the nematodes varied considerably, with most individuals persisting for weeks whereas others were degraded within several days and appeared to be colonized by dense hyphal growth. This study provides the first documentation of a non-agaricoid fungus producing secretory cells that are able to immobilize nematodes.

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There has been strong demand for enhancement techniques of single-phase forced convection heat transfer because of its wide area of application on the one side and because of inferior heat-transfer capability, when compared with phase change heat transfer such as boiling and condensation, on the other side. The enhancement techniques are indispensable when gases are used as heat-transfer media. In this article the basic principles of enhancement of single-phase forced convection heat transfer are described in the first place. Three principal techniques currently employed, i..,(a) interrupted fins, (b) twisted tapes, and (c) turbulence promoters, are introduced. Mechanisms of heat-tansfer enhancement and the state-of-the art review on the R&D are presented for these techniques. In addition to these, supplementary remarks are given on techniques utilizing multiphase flow and electrostatic field.

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The title compound, bearing a twenty-membered ring, was synthesized by macrolactonization of a hydroxy carboxylic acid. The structure was investigated by X-ray crystallography. The compound crystallizes in the monoclinic system, space group P2₁/c. In the crystal, two remarkable kinds of interactions between two ester groups and between two arylacetylene moieties were detected.

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Activity-directed isolation of the ethyl acetate, methylene chloride and n-hexane fractions of Gloiopeltis furcata resulted in the isolation of 18 compounds. Their structures were elucidated as 2-(3-hydroxy--oxotetrahydrofuran-3-yl)acetic acid (1), glutaric acid (2), succinic acid (3), nicotinic acid (4), ()-4-hydroxyhex-2-enoic acid (), cholesterol (6), -hydroxycholesterol (), uridine (8), glycerol (), -(hydroxymethyl)-2-methoxybenzene-1,3-diol (10), (,)--oxodeca-,-dienoic acid (11), (Z)-3-ethylidene-4-methylpyrrolidine-2,-dione (12), dehydrovomifoliol (13), loliolide (14), cholesteryl stearate (15), palmitic acid (16), cis-,8,11,14,17-eicosapentaenoic acid (17) and α-linolenic acid (18) on the basis of spectroscopic and chemical evidences. Their anticholinesterase and antioxidant activities were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as well as scavenging activities on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO⁻). All isolated compounds (1—18) exhibited moderate AChE inhibitory activities with IC₅₀ values ranging from 1.14—12.50 μg/ml, whereas 1, , , 17, and 18 showed mild BChE inhibitory activities with IC₅₀ values ranging from .57—15.89 μg/ml. Although most of the compounds isolated were lacking the scavenging activity on DPPH radical and ONOO⁻, and 10 showed good DPPH radical scavenging activity, and , 10, and 16 showed potent ONOO⁻ scavenging activity.

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Alfven resonance effects on the evolution of a magnetic island driven by an externally applied perturbation are investigated for rotating plasmas. The simulation results show the importance of Alfven resonance for obtaining a perturbed current profile and estimating a critical value of the external perturbation, beyond which the magnetic island grows rapidly. The nonlinear evolution of the externally driven magnetic island is also investigated at low and high viscosities ν. It is shown that the transition phase accompanying the secondary reconnection at the initial X-point in the driven magnetic island evolution occurs in low resistivity and viscosity plasmas.

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Eight new sterols, , 8α-epidioxy-(, 24R)-23-methylergosta-6, -dien-3β-ol (1), 3β, , -trihydroxy-(, 24R)-23-methylergosta-, -dien-6-one (2), 3β, , -trihydroxy-(24S)-ergost--en-6-one (3), 3β, , , 14α-tetrahydroxy-(, 24R)-ergosta-, -dien-6-one (4), (, 24R)-ergosta-, -diene-3β, , 6α, -tetrol (), , -epidioxy-3β-hydroxy-(, 24R)-ergosta-, -dien-6-one (6), , -epidioxy-3β-hydroxy-(24S)-ergost--en-6-one () and , 6α-epoxy-(, 24R)-ergosta-8, -diene-3β, , 14α-triol (8), have been isolated from five edible mushrooms, Lentinus edodes, Flammulina velutipes, Hypsizigus marmoreus, Pleurotus ostreatus and Pholiota nameko together with fifteen known ones (-23), of which two (16 and 17) are reported for the first time from a fungal source. The structures of these new compounds were elucidated on the basis of their spectral data.

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Stereoselective synthesis of , - and , Z-β-ionylideneacetaldehydes was accomplished from the β-ionone tricarbonyl iron complex, and the latter was converted to Z-retinoic acid.

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Six new sterols, , 6α;8α, -diepoxy-(, 24R)-ergost--ene-3β, -diol (1), , 6α;8α, -diepoxy-(, 24R)-ergost--ene-3β, -diol (2), , 6α-epoxy-(, 24R)-ergosta-8, -diene-3β, -diol (3), (, 24R)-23-methylergosta-, -diene-3β, , 6β-triol (4), (, 24R)-23-methulergosta-, -diene-3β, , 6β, -tetrol () and (24S)-ergost--ene-3β, , 6β, -tetrol (6), have been isolated from seven mushrooms, Amanita pantherina, Amantia virgineoides, Lactarius piperatus, Lyophyllum shimeji, Tricholoma portentosum, Hypsizigus marmoreus and Lentinula edodes together with eighteen known ones (-24). The structures of these new compounds were elucidated on the basis of their spectral data.

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We have discussed the resolution of submicron photoluminescence (PL) imaging using a solid immersion lens (SIL), which collects an evanescent light field. We apply the SIL microscope to measure PL image of a strip-line-patterned GaAs quantum well structure at low temperature. An improved resolution beyond diffraction limit and high collection efficiency of PL are realized.

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背景と目的：ステロイド性骨粗鬆症は，積極的な治療介入が必要とされる．その第一選択薬はビスホスホネート製剤（以下ビス）であるが，近年，デノスマブ（以下デノス）も注目を浴びている．ステロイド性骨粗鬆症の骨密度に対する両者の効果を比較検討した．

方法：ステロイド性骨粗鬆症の管理と治療ガイドライン：2014年改訂版の薬物療法開始の基準を満たした患者を対象とした．無治療群（N群）と，治療介入群として当初よりビスで治療したBB群，ビス後デノスに変更したBD群，デノスで治療したDD群，デノス後ビスに変更したDB群を抽出し，ステロイド投与を開始した時，ステロイド性骨粗鬆症に対する治療を開始した時または薬剤変更から6カ月後の腰椎，大腿骨頚部と大転子部の骨密度を測定し，それらの変化を統計学的に比較検討した．

結果：149例が抽出され，その内訳は，N群48例，BB群24例，BD群

例，DD群21例，DB群34例であった．治療開始時または薬剤変更から6カ月後にBD群を除くすべての治療介入群で腰椎の骨密度が上昇した．大腿骨の骨密度は，BD群において薬剤変更後に上昇に転じた．

考察：デノスにはビスと同様の骨密度上昇効果があると考えられた．

結論：デノスは，ステロイド性骨粗鬆症治療の第一選択薬となり得る．

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One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.

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