Over the past decade, urban development in Tokyo has incentivized residential buildings’ creation rather than promoting a mixture of activities. An example of existing mixity in Tokyo is the classified residence-combined factory. However, those buildings are disappearing due to urban change. This paper draws upon fieldwork and interviews conducted in Sumida ward. It brings forward the socio-spatial aspects of living and working in the same building and investigates the spatial composition focusing on the connection between industrial and residential function. As a result, we obtained a series of typologies of residence-combined factories and discussed their potential for the contemporary city.