Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Effect of Valerian Extract Preparation (BIM) on the Sleep-Wake Cycle in Rats
Shin TokunagaYasuhiro TakedaTsuyoshi NiimotoNorihisa NishidaToshihiro KuboTohru OhnoYouichi MatsuuraYuzo KawaharaKazuaki ShinomiyaChiaki Kamei
ジャーナル フリー

2007 年 30 巻 2 号 p. 363-366


In the present study, we studied the effect of valerian extract preparation (BIM) containing valerian extract, golden root (Rhodiola rosea L.) extract and L-theanine (γ-glutamylethylamide) on the sleep-wake cycle using sleep-disturbed model rats in comparison with that of valerian extract. A significant shortening in sleep latency was observed with valerian extract and the BIM at a dose of 1000 mg/kg. On the other hand, valerian extract and the BIM caused no significant effects on total times of wakefulness, non-rapid eye movement (non-REM) sleep and REM sleep. Valerian extract and the BIM at a dose of 1000 mg/kg also had no significant effect on delta activity. In conclusion, it became clear that the BIM could be useful as a herbal medicine having a sleep-inducing effect without causing an alteration of the sleep-wakefulness cycle.

© 2007 The Pharmaceutical Society of Japan
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