Synthesis and Antiviral Activities of Some 4,4′- and 2,2′-Dihydroxytriphenylmethanes

抄録

We synthesized some 4,4′- and 2,2′-dihydroxytriphenylmethane derivatives 3a—e and 4a—c by condensation of phenol 1 and aromatic aldehyde 2 in moderate to good yields (30—83%). Most of them showed significant antiviral activity against herpes simplex virus type 1 (anti-HSV-1 activity) in a plaque reduction assay. The most potent antiviral activity (EC₅₀=0.79 μg/ml) was observed in the 4,4′-dihydroxytriphenylmethane derivative 3b. This compound 3b showed lower cytotoxicity (CC₅₀=30.2 μg/ml), compared to that of the prototype 3a.