Detection of C-Reactive Protein in Serum Using Resonant Property of Quartz Crystal Microbalance

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We investigated the resonant property of a quartz crystal microbalance (QCM) for C-reactive protein (CRP) detection using immunoagglutination technique of anti-CRP antibody immobilized latex beads. Serum containing CRP was added to the immunized latex-bead suspension. The immunized latex beads were agglutinated and adsorbed onto the QCM electrode surface. Based on the adsorption of agglutinated latex beads onto the QCM, the shifts of increasing impedance and decreasing resonance frequency were proportional to the CRP concentration in the serum.