Administration of cyclodextrin-ferulic acid complex significantly increases the plasma concentration of the intact form of ferulic acid in mice

Abstract

We previously demonstrated that dietary ferulic acid (FA) (10 g FA/kg diet) significantly suppressed white adipose tissue (WAT) deposits and body weight gain via induction of beige adipocyte formation in mice. However, a lower dose of FA (2 g FA/kg diet) did not significantly suppress fat deposits or induce beige adipocyte formation due to low bioavailability. In the present study, we found that administration of α-cyclodextrin-FA complex (CD-FA) to mice significantly elevated the FA concentration in plasma and inguinal WAT. In particular, CD-FA administration significantly increased the intact form of FA in plasma, suggesting that it can be expected to enhance the induction of beige adipocyte formation at a lower dose. However, a CD-FA-supplemented diet (12.4 g CD-FA/kg, including 2.0 g FA/kg) did not significantly induce beige adipocyte formation. To reduce the required functional dose of FA, the further development of bioavailable FA formulations should be investigated.